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  • Reply to: Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition.   9 hours 19 sec ago

    The treatment might be useful to reduce woman's AD occurrence rate

  • Reply to: "Missed" Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria.   3 days 20 hours ago

    This is a relevant finding for clinical trials (particularly for the inclusion of control cases) 

  • Reply to: Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition.   3 days 20 hours ago

    A treatment able to reduce beta-amyloid deposition

  • Reply to: Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers.   3 days 20 hours ago

    This paper tried to include several markers, including cognition, to reach a diagnosis in individual basis. This paper deals with real life problem in AD 

  • Reply to: Crowd Sourcing Literature Reviews   1 week 3 days ago

    Hi Aaron,

    The papers you listed are certainly landmarks. The problem I see is that in a field as broad as AD research, is it fair to try to reduce the entire field to the 40 top papers? Also, it is possible that some fields of AD (APOE genetics) tend to procude higher rates of citations than, let's say, membrane-amyloid interactions. In a field this broad, you'd almost have to look at the top 40 papers dealing with genetics, AB, tau, neuro imaging, etc.

    WRT retracted papers, that is a very difficult question to answer. Some papers are retracted because a junior author fabricated results. Should the entire paper be thrown out because, let's say, one figure of Western Blots was altered, but the remainder of the data is sound? I would tend to err on the side of caution and leave the whole thing out. Where there's smoke, there's fire. I respect if others disagree though.

    I ran into a someone similar problem in preparing part 1 of this review. The paper by Cramer et al. (Cramer, Science, 2012) dealing with bexarotene to clear AB, contained results that other groups had difficulty in replicating. I included the Cramer paper in the review but also made a note that numerous other groups could not replicate the results in their entirety. This lets the reader decide for themselves how they wish to weight the evidence.

  • Reply to: Crowd Sourcing Literature Reviews   1 week 3 days ago

    Francis,
    I very much liked reading your ideas regarding the use of AI to help in the process of writing a review article. In an AD bibliometric analysis last year (https://rd.springer.com/article/10.1007/s11192-016-2119-7 -- see figure 5), some colleagues and I and used a simple form of AI to select the forty most salient articles in the literature describing the use of transgenic mice to investigate the role of amyloid beta-protein precursor in AD. Below is the list of forty papers that the citation-network-driven algorithm produced.

    Something interesting that came out of the analysis was the fact that a retracted paper (Kawabata et al. [1991]) was included in the forty recommended papers. As you can imagine it caused a debate among the coauthors regarding whether certain retractions can still be viewed as important milestones in the history of a given subfield of science.

    I would be curious to year thoughts regarding the list of forty. Are there any oblivious false positives or any papers which were left off the list which clearly should have been included? Any advice on general rules to apply before running the algorithm (e.g. eliminate all retracted papers).

    Regards,
    Aaron

    Year Published

    Authors

    Title

    Journal

    Paper Type

    1991

    KAWABATA, S; HIGGINS, GA; GORDON, JW

    AMYLOID PLAQUES, NEUROFIBRILLARY TANGLES AND NEURONAL LOSS IN BRAINS OF TRANSGENIC MICE OVEREXPRESSING A C-TERMINAL FRAGMENT OF HUMAN AMYLOID PRECURSOR PROTEIN (RETRACTED ARTICLE. SEE VOL 356, PG 265, 1992)

    NATURE

    Article

    1991

    WIRAK, DO; BAYNEY, R; KUNDEL, CA; LEE, A; SCANGOS, GA; TRAPP, BD; UNTERBECK, AJ

    REGULATORY REGION OF HUMAN AMYLOID PRECURSOR PROTEIN (APP) GENE PROMOTES NEURON-SPECIFIC GENE-EXPRESSION IN THE CNS OF TRANSGENIC MICE

    EMBO J

    Article

    1991

    QUON, D; WANG, Y; CATALANO, R; SCARDINA, JM; MURAKAMI, K; CORDELL, B

    FORMATION OF BETA-AMYLOID PROTEIN DEPOSITS IN BRAINS OF TRANSGENIC MICE

    NATURE

    Article

    1991

    WIRAK, DO; BAYNEY, R; RAMABHADRAN, TV; FRACASSO, RP; HART, JT; HAUER, PE; HSIAU, P; PEKAR, SK; SCANGOS, GA; TRAPP, BD; UNTERBECK, AJ

    DEPOSITS OF AMYLOID-BETA PROTEIN IN THE CENTRAL-NERVOUS-SYSTEM OF TRANSGENIC MICE

    SCIENCE

    Article

    1994

    HIGGINS, LS; HOLTZMAN, DM; RABIN, J; MOBLEY, WC; CORDELL, B

    TRANSGENIC MOUSE-BRAIN HISTOPATHOLOGY RESEMBLES EARLY ALZHEIMERS-DISEASE

    ANN NEUROL

    Article

    1995

    GAMES, D; ADAMS, D; ALESSANDRINI, R; BARBOUR, R; BERTHELETTE, P; BLACKWELL, C; CARR, T; CLEMENS, J; DONALDSON, T; GILLESPIE, F; GUIDO, T; HAGOPIAN, S; JOHNSONWOOD, K; KHAN, K; LEE, M; LEIBOWITZ, P; LIEBERBURG, I; LITTLE, S; MASLIAH, E; MCCONLOGUE, L; MONTOYAZAVALA, M; MUCKE, L; PAGANINI, L; PENNIMAN, E; POWER, M; SCHENK, D; SEUBERT, P; SNYDER, B; SORIANO, F; TAN, H; VITALE, J; WADSWORTH, S; WOLOZIN, B; ZHAO, J

    ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN

    NATURE

    Article

    1995

    HSIAO, KK; BORCHELT, DR; OLSON, K; JOHANNSDOTTIR, R; KITT, C; YUNIS, W; XU, S; ECKMAN, C; YOUNKIN, S; PRICE, D; IADECOLA, C; CLARK, HB; CARLSON, G

    AGE-RELATED CNS DISORDER AND EARLY DEATH IN TRANSGENIC FVB/N MICE OVEREXPRESSING ALZHEIMER AMYLOID PRECURSOR PROTEINS

    NEURON

    Article

    1995

    ROCKENSTEIN, EM; MCCONLOGUE, L; TAN, H; POWER, M; MASLIAH, E; MUCKE, L

    LEVELS AND ALTERNATIVE SPLICING OF AMYLOID-BETA PROTEIN-PRECURSOR (APP) TRANSCRIPTS IN BRAINS OF APP TRANSGENIC MICE AND HUMANS WITH ALZHEIMERS-DISEASE

    J BIOL CHEM

    Article

    1995

    LAFERLA, FM; TINKLE, BT; BIEBERICH, CJ; HAUDENSCHILD, CC; JAY, G

    THE ALZHEIMERS A-BETA PEPTIDE INDUCES NEURODEGENERATION AND APOPTOTIC CELL-DEATH IN TRANSGENIC MICE

    NAT GENET

    Article

    1996

    Hsiao, K; Chapman, P; Nilsen, S; Eckman, C; Harigaya, Y; Younkin, S; Yang, FS; Cole, G

    Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice

    SCIENCE

    Article

    1996

    Masliah, E; Sisk, A; Mallory, M; Mucke, L; Schenk, D; Games, D

    Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

    J NEUROSCI

    Article

    1997

    Irizarry, MC; Soriano, F; McNamara, M; Page, KJ; Schenk, D; Games, D; Hyman, BT

    A beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse

    J NEUROSCI

    Article

    1997

    JohnsonWood, K; Lee, M; Motter, R; Hu, K; Gordon, G; Barbour, R; Khan, K; Gordon, M; Tan, H; Games, D; Lieberburg, I; Schenk, D; Seubert, P; McConlogue, L

    Amyloid precursor protein processing and A beta(42) deposition in a transgenic mouse model of Alzheimer disease

    P NATL ACAD SCI USA

    Article

    1998

    Calhoun, ME; Wiederhold, KH; Abramowski, D; Phinney, AL; Probst, A; Sturchler-Pierrat, C; Staufenbiel, M; Sommer, B; Jucker, M

    Neuron loss in APP transgenic mice

    NATURE

    Letter

    1999

    Hsia, AY; Masliah, E; McConlogue, L; Yu, GQ; Tatsuno, G; Hu, K; Kholodenko, D; Malenka, RC; Nicoll, RA; Mucke, L

    Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

    P NATL ACAD SCI USA

    Article

    2000

    Mucke, L; Masliah, E; Yu, GQ; Mallory, M; Rockenstein, EM; Tatsuno, G; Hu, K; Kholodenko, D; Johnson-Wood, K; McConlogue, L

    High-level neuronal expression of A beta(1-42) in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation

    J NEUROSCI

    Article

    2000

    Morgan, D; Diamond, DM; Gottschall, PE; Ugen, KE; Dickey, C; Hardy, J; Duff, K; Jantzen, P; DiCarlo, G; Wilcock, D; Connor, K; Hatcher, J; Hope, C; Gordon, M; Arendash, GW

    A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

    NATURE

    Article

    2001

    Koistinaho, M; Ort, M; Cimadevilla, JM; Vondrous, R; Cordell, B; Koistinaho, J; Bures, J; Higgins, LS

    Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques

    P NATL ACAD SCI USA

    Article

    2002

    Selkoe, DJ

    Alzheimer's disease is a synaptic failure

    SCIENCE

    Article

    2002

    Dodart, JC; Bales, KR; Gannon, KS; Greene, SJ; DeMattos, RB; Mathis, C; DeLong, CA; Wu, S; Wu, X; Holtzman, DM; Paul, SM

    Immunization reverses memory deficits without reducing brain A beta burden in Alzheimer's disease model

    NAT NEUROSCI

    Article

    2003

    Oddo, S; Caccamo, A; Shepherd, JD; Murphy, MP; Golde, TE; Kayed, R; Metherate, R; Mattson, MP; Akbari, Y; LaFerla, FM

    Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular A beta and synaptic dysfunction

    NEURON

    Article

    2003

    Kamenetz, F; Tomita, T; Hsieh, H; Seabrook, G; Borchelt, D; Iwatsubo, T; Sisodia, S; Malinow, R

    APP processing and synaptic function

    NEURON

    Article

    2004

    Ohno, M; Sametsky, EA; Younkin, LH; Oakley, H; Younkin, SG; Citron, M; Vassar, R; Disterhoft, JF

    BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

    NEURON

    Article

    2005

    Kobayashi, DT; Chen, KS

    Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease

    GENES BRAIN BEHAV

    Review

    2005

    Chin, J; Palop, JJ; Puolivali, J; Massaro, C; Bien-Ly, N; Gerstein, H; Scearce-Levie, K; Masliah, E; Mucke, L

    Fyn kinase induces synaptic and cognitive impairments in a Transgenic mouse model of Alzheimer's disease

    J NEUROSCI

    Article

    2006

    Esposito, L; Raber, J; Kekonius, L; Yan, FR; Yu, GQ; Bien-Ly, N; Puolivali, J; Scearce-Levie, K; Masliah, E; Mucke, L

    Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice

    J NEUROSCI

    Review

    2007

    Palop, JJ; Chin, J; Roberson, ED; Wang, J; Thwin, MT; Bien-Ly, N; Yoo, J; Ho, KO; Yu, GQ; Kreitzer, A; Finkbeiner, S; Noebels, JL; Mucke, L

    Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

    NEURON

    Article

    2007

    Cheng, IH; Scearce-Levie, K; Legleiter, J; Palop, JJ; Gerstein, H; Bien-Ly, N; Puolivali, J; Lesne, S; Ashe, KH; Muchowski, PJ; Mucke, L

    Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

    J BIOL CHEM

    Article

    2008

    Meilandt, WJ; Yu, GQ; Chin, J; Roberson, ED; Palop, JJ; Wu, T; Scearce-Levie, K; Mucke, L

    Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease

    J NEUROSCI

    Article

    2009

    Palop, JJ; Mucke, L

    Epilepsy and Cognitive Impairments in Alzheimer Disease

    ARCH NEUROL-CHICAGO

    Review

    2010

    Harris, JA; Devidze, N; Halabisky, B; Lo, I; Thwin, MT; Yu, GQ; Bredesen, DE; Masliah, E; Mucke, L

    Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

    J NEUROSCI

    Article

    2010

    Harris, JA; Devidze, N; Verret, L; Ho, K; Halabisky, B; Thwin, MT; Kim, D; Hamto, P; Lo, I; Yu, GQ; Palop, JJ; Masliah, E; Mucke, L

    Transsynaptic Progression of Amyloid-beta-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

    NEURON

    Article

    2011

    Bero, AW; Yan, P; Roh, JH; Cirrito, JR; Stewart, FR; Raichle, ME; Lee, JM; Holtzman, DM

    Neuronal activity regulates the regional vulnerability to amyloid-beta deposition

    NAT NEUROSCI

    Article

    2012

    Sanchez, PE; Zhu, L; Verret, L; Vossel, KA; Orr, AG; Cirrito, JR; Devidze, N; Ho, K; Yu, GQ; Palop, JJ; Mucke, L

    Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

    P NATL ACAD SCI USA

    Article

    2012

    Verret, L; Mann, EO; Hang, GB; Barth, AMI; Cobos, I; Ho, K; Devidze, N; Masliah, E; Kreitzer, AC; Mody, I; Mucke, L; Palop, JJ

    Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

    CELL

    Article

    2013

    Corbett, BF; Leiser, SC; Ling, HP; Nagy, R; Breysse, N; Zhang, XH; Hazra, A; Wood, A; Pangalos, MN; Reinhart, PH; Chin, J

    Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

    J NEUROSCI

    Article

    2014

    Tai, LM; Koster, KP; Luo, J; Lee, SH; Wang, YT; Collins, NC; Ben Aissa, M; Thatcher, GRJ; LaDu, MJ

    Amyloid-beta Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo

    J BIOL CHEM

    Article

    2014

    Born, HA; Kim, JY; Savjani, RR; Das, P; Dabaghian, YA; Guo, QX; Yoo, JW; Schuler, DR; Cirrito, JR; Zheng, H; Golde, TE; Noebels, JL; Jankowsky, JL

    Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

    J NEUROSCI

    Article

    2014

    Fowler, SW; Chiang, ACA; Savjani, RR; Larson, ME; Sherman, MA; Schuler, DR; Cirrito, JR; Lesne, SE; Jankowsky, JL

    Genetic Modulation of Soluble A beta Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

    J NEUROSCI

    Article

    2015

    Liu, DS; Pan, XD; Zhang, J; Shen, H; Collins, NC; Cole, AM; Koster, KP; Ben Aissa, M; Dai, XM; Zhou, M; Tai, LM; Zhu, YG; LaDu, MJ; Chen, XC

    APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

    MOL NEURODEGENER

    Article