Title | MIND Diet, Common Brain Pathologies, and Cognition in Community-Dwelling Older Adults. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Dhana, K, James, BD, Agarwal, P, Aggarwal, NT, Cherian, LJ, Leurgans, SE, Barnes, LL, Bennett, DA, Schneider, JA |
Journal | J Alzheimers Dis |
Volume | 83 |
Issue | 2 |
Pagination | 683-692 |
Date Published | 2021 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyloid, Autopsy, Brain, Chicago, Cognition, Diet, Mediterranean, Female, Humans, Independent Living, Longitudinal Studies, Male, Neuropsychological Tests, Surveys and Questionnaires |
Abstract | BACKGROUND: MIND diet, a hybrid of the Mediterranean diet and the Dietary Approaches to Stop Hypertension diet, is associated with a slower cognitive decline and lower risk of Alzheimer's disease (AD) dementia in older adults. OBJECTIVE: We aim to examine whether the association of the MIND diet with cognition is independent of common brain pathologies. METHODS: Utilizing data from the Rush Memory and Aging Project (MAP), a longitudinal clinical-pathologic study, we studied 569 decedents with valid dietary data, cognitive testing proximate to death, and complete autopsy data at the time of these analyses. A series of regression analyses were used to examine associations of the MIND diet, dementia-related brain pathologies, and global cognition proximate to death adjusting for age, sex, education, APOEɛ4, late-life cognitive activities, and total energy intake. RESULTS: A higher MIND diet score was associated with better global cognitive functioning proximate to death (β= 0.119, SE = 0.040, p = 0.003), and neither the strength nor the significance of association changed substantially when AD pathology and other brain pathologies were included in the model. The β-estimate after controlling for global AD pathology was 0.111 (SE = 0.037, p = 0.003). The MIND diet-cognition relationship remained significant when we restricted our analysis to individuals without mild cognitive impairment at the baseline (β= 0.121, SE = 0.042, p = 0.005) or in people diagnosed with postmortem diagnosis of AD based on NIA-Reagan consensus recommendations (β= 0.114, SE = 0.050, p = 0.023). CONCLUSION: MIND diet is associated with better cognitive functioning independently of common brain pathology, suggesting that the MIND diet may contribute to cognitive resilience in the elderly. |
DOI | 10.3233/JAD-210107 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 34334393 |
PubMed Central ID | PMC8480203 |
Grant List | K01 AG050823 / AG / NIA NIH HHS / United States R01 AG017917 / AG / NIA NIH HHS / United States R01 AG054476 / AG / NIA NIH HHS / United States R21 AG070287 / AG / NIA NIH HHS / United States |
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