| Title | Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Yoo, TJune |
| Journal | J Alzheimers Dis |
| Volume | 85 |
| Issue | 3 |
| Pagination | 1001-1008 |
| Date Published | 2022 |
| ISSN | 1875-8908 |
| Keywords | Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Anti-Inflammatory Agents, Cognition, Disease Models, Animal, Female, Genetic Therapy, Immunity, Cellular, Immunotherapy, Injections, Intramuscular, Interleukin-10, Interleukin-4, Male, Mice, Mice, Transgenic, Spatial Memory |
| Abstract | The immune system plays a critical role in neurodegenerative processes involved in Alzheimer's disease (AD). In this study, a gene-based immunotherapeutic method examined the effects of anti-inflammatory cellular immune response elements (CIREs) in the amyloid-β protein precursor (AβPP) mouse model. Bi-monthly intramuscular administration, beginning at either 4 or 6 months, and examined at 7.5 through 16 months, with plasmids encoding Interleukin (IL)-10, IL-4, TGF-β polynucleotides, or a combination thereof, into AβPP mice improved spatial memory performance. This work demonstrates an efficient gene therapy strategy to downregulate neuroinflammation, and possibly prevent or delay cognitive decline in AD. |
| DOI | 10.3233/JAD-215270 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 34897091 |
| PubMed Central ID | PMC8925118 |
| Grant List | R01 DC005010 / DC / NIDCD NIH HHS / United States |
