Title | Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Yoo, TJune |
Journal | J Alzheimers Dis |
Volume | 85 |
Issue | 3 |
Pagination | 1001-1008 |
Date Published | 2022 |
ISSN | 1875-8908 |
Keywords | Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Anti-Inflammatory Agents, Cognition, Disease Models, Animal, Female, Genetic Therapy, Immunity, Cellular, Immunotherapy, Injections, Intramuscular, Interleukin-10, Interleukin-4, Male, Mice, Mice, Transgenic, Spatial Memory |
Abstract | The immune system plays a critical role in neurodegenerative processes involved in Alzheimer's disease (AD). In this study, a gene-based immunotherapeutic method examined the effects of anti-inflammatory cellular immune response elements (CIREs) in the amyloid-β protein precursor (AβPP) mouse model. Bi-monthly intramuscular administration, beginning at either 4 or 6 months, and examined at 7.5 through 16 months, with plasmids encoding Interleukin (IL)-10, IL-4, TGF-β polynucleotides, or a combination thereof, into AβPP mice improved spatial memory performance. This work demonstrates an efficient gene therapy strategy to downregulate neuroinflammation, and possibly prevent or delay cognitive decline in AD. |
DOI | 10.3233/JAD-215270 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 34897091 |
PubMed Central ID | PMC8925118 |
Grant List | R01 DC005010 / DC / NIDCD NIH HHS / United States |