Journal of Alzheimer's Disease
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Home > Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease.

TitleAnti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2022
AuthorsYoo, TJune
JournalJ Alzheimers Dis
Volume85
Issue3
Pagination1001-1008
Date Published2022
ISSN1875-8908
KeywordsAlzheimer Disease, Amyloid beta-Protein Precursor, Animals, Anti-Inflammatory Agents, Cognition, Disease Models, Animal, Female, Genetic Therapy, Immunity, Cellular, Immunotherapy, Injections, Intramuscular, Interleukin-10, Interleukin-4, Male, Mice, Mice, Transgenic, Spatial Memory
Abstract

The immune system plays a critical role in neurodegenerative processes involved in Alzheimer's disease (AD). In this study, a gene-based immunotherapeutic method examined the effects of anti-inflammatory cellular immune response elements (CIREs) in the amyloid-β protein precursor (AβPP) mouse model. Bi-monthly intramuscular administration, beginning at either 4 or 6 months, and examined at 7.5 through 16 months, with plasmids encoding Interleukin (IL)-10, IL-4, TGF-β polynucleotides, or a combination thereof, into AβPP mice improved spatial memory performance. This work demonstrates an efficient gene therapy strategy to downregulate neuroinflammation, and possibly prevent or delay cognitive decline in AD.

DOI10.3233/JAD-215270
Alternate JournalJ Alzheimers Dis
PubMed ID34897091
PubMed Central IDPMC8925118
Grant ListR01 DC005010 / DC / NIDCD NIH HHS / United States
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Source URL: https://www.j-alz.com/content/anti-inflammatory-gene-therapy-improves-spatial-memory-performance-mouse-model-alzheimers