Title | Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer's Disease Mouse Model. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Manousopoulou, A, Saito, S, Yamamoto, Y, Al-Daghri, NM, Ihara, M, Carare, RO, Garbis, SD |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 2 |
Pagination | 333-8 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Alzheimer Disease, Animals, Brain, Disease Models, Animal, Functional Laterality, Male, Mice, Transgenic, Nootropic Agents, Proteome, Tetrazoles |
Abstract | The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer's disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets. |
DOI | 10.3233/JAD-151078 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26836196 |
PubMed Central ID | PMC4927832 |
Grant List | / / Biotechnology and Biological Sciences Research Council / United Kingdom |