Title | Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Hong, X-P, Chen, T, Yin, N-N, Han, Y-M, Yuan, F, Duan, Y-J, Shen, F, Zhang, Y-H, Bin Chen, Z- |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 2 |
Pagination | 605-17 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Animals, Cognition Disorders, Disease Models, Animal, Fibroblast Growth Factor 2, Galactose, Glycogen Synthase Kinase 3, Hippocampus, Isoflavones, Male, Maze Learning, Neurogenesis, Neurons, Neuroprotective Agents, Phosphorylation, Random Allocation, Rats, Sprague-Dawley, Signal Transduction, Spatial Memory, tau Proteins |
Abstract | Enhanced neurogenesis has been reported in the hippocampus of patients with Alzheimer's disease (AD), the most common neurodegenerative disorder characterized with amyloid-β (Aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. Previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (GSK-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. In the present study, we found that treatment of D-galactose rats with Puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of D-galactose rat brains. FGF-2/GSK-3 signaling pathway might be involved in the effects of Puerarin on hippocampal neurogenesis and tau hyperphosphorylation. Our finding provides primary in vivo evidence that Puerarin can attenuate AD-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. Our finding also suggests Puerarin can be served as a treatment for age-related neurodegenerative disorders, such as AD. |
DOI | 10.3233/JAD-150566 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26890737 |