| Title | Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | van Doorn, LJC van Wa, Gispert, JD, H Kuiperij, B, Claassen, JAHR, Arighi, A, Baldeiras, I, Blennow, K, Bozzali, M, Castelo-Branco, M, Cavedo, E, Emek-Savaş, DD, Eren, E, Eusebi, P, Farotti, L, Fenoglio, C, Ormaechea, JFortea, Freund-Levi, Y, Frisoni, GB, Galimberti, D, Genc, S, Greco, V, Hampel, H, Herukka, S-K, Liu, Y, Lladó, A, Lleo, A, Nobili, FM, Oguz, KK, Parnetti, L, Pereira, J, Picco, A, Pikkarainen, M, de Oliveira, CResende, Saka, E, Salvadori, N, Sánchez-Valle, R, Santana, I, Scarpini, E, Scheltens, P, Soininen, H, Tarducci, R, Teunissen, C, Tsolaki, M, Urbani, A, Vilaplana, E, Visser, PJelle, Wallin, AK, Yener, G, Molinuevo, JL, Meulenbroek, O, Verbeek, MM |
| Journal | J Alzheimers Dis |
| Volume | 56 |
| Issue | 2 |
| Pagination | 543-555 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r = -0.28; p |
| DOI | 10.3233/JAD-160668 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28059783 |
