Title | Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lombardi, G, Berti, V, Tedde, A, Bagnoli, S, Piaceri, I, Polito, C, Lucidi, G, Ferrari, C, Ginestroni, A, Moretti, M, Pupi, A, Nacmias, B, Sorbi, S |
Journal | J Alzheimers Dis |
Volume | 57 |
Issue | 3 |
Pagination | 697-703 |
Date Published | 2017 |
ISSN | 1875-8908 |
Keywords | Alanine, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Aniline Compounds, Brain, Ethylene Glycols, Humans, Male, Middle Aged, Mutation, Peptide Fragments, Positron-Emission Tomography, Threonine |
Abstract | According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental. |
DOI | 10.3233/JAD-161170 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28304299 |