| Title | Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer's Disease Brains. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Villamil-Ortiz, JGustavo, Barrera-Ocampo, A, Arias-Londoño, JDavid, Villegas, A, Lopera, F, Cardona-Gómez, GPatricia |
| Journal | J Alzheimers Dis |
| Volume | 61 |
| Issue | 1 |
| Pagination | 209-219 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Keywords | Adult, Aged, Aged, 80 and over, Alanine, Alzheimer Disease, Analysis of Variance, Fatty Acids, Female, Gene Expression Regulation, Glutamic Acid, Humans, Lysophosphatidylcholines, Male, Mass Spectrometry, Middle Aged, Mutation, Phosphatidylethanolamines, Phospholipids, Presenilin-1, Temporal Lobe |
| Abstract | Lipids are considered important factors in the pathogenesis of Alzheimer's disease (AD). In this study, we realized a comparative analysis of the phospholipid profile and phospholipid composition of the temporal cortex from E280A-familiar AD (FAD), sporadic AD (SAD), and healthy human brains. Findings showed a significant decrease of lysophosphatidylcholine and phosphatidylethanolamine formed by low levels of polyunsaturated fatty acids (20 : 4, 22 : 6) in AD brains. However, phosphatidylethanolamine-ceramide and phosphoglycerol were significantly increased in SAD, conformed by high levels of (18 : 0/18 : 1) and (30/32/36 : 0/1/2), respectively. Together, the findings suggest a deficiency in lysophosphacholine and phosphatidylethanolamine, and alteration in the balance between poly- and unsaturated fatty acids in both types of AD, and a differential pattern of phospholipid profile and fatty acid composition between E280A FAD and SAD human brains. |
| DOI | 10.3233/JAD-170554 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 29125487 |
