Title | Decreased Prefrontal Activation during Matrix Reasoning in Predementia Progranulin Mutation Carriers. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Alexander, C, Zeithamova, D, Hsiung, G-YR, Mackenzie, IR, Jacova, C |
Journal | J Alzheimers Dis |
Volume | 62 |
Issue | 2 |
Pagination | 583-589 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Adult, Biomarkers, Female, Frontotemporal Dementia, Functional Neuroimaging, Heterozygote, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Prefrontal Cortex, Progranulins |
Abstract | We tested the potential of task-based functional neuroimaging as a biomarker of emerging prefrontal brain changes in progranulin (GRN) mutations carriers. Five GRN mutation carriers free of frontotemporal dementia (FTD) and 11 non-carriers from families with FTD-GRN underwent functional MRI while solving matrix-reasoning problems. Mutation carriers displayed slower responses for more difficult problems and lower lateral prefrontal activation across all problems. Overall task-evoked posterior ventrolateral prefrontal activation predicted mutation status with 100% sensitivity and 91% specificity. Volumetric differences did not account for activation differences. Prefrontal activation may have utility as a biomarker in GRN mutation. |
DOI | 10.3233/JAD-170716 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29480174 |
Grant List | 179009 / / CIHR / Canada |