2021 Alzheimer AwardAIAD Vol.8Jack de la Torre blogCOVID-19 contentAppmiceBook and manICCmapsAIAD Vol.7 (TBI)PTXcognitivedeclineJAD70:s1 IRNDPSTEDJAD Reports (updated)leptomeningeal

The 2021 Alzheimer Award goes to Giulio Taglialatela, PhD, and Balaji Krishnan , PhD, as co-authors of the winning JAD paper that explores why certain individuals remain cognitively intact despite changes to the brain normally associated with fully symptomatic AD. For details, go to: j-alz.com/award 

This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here

LATEST JAD EDITORS’ BLOG
What is the Purpose of Medicine When Dealing with Incurable Alzheimer’s Disease?

by Jack de la Torre, MD, PhD

COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19

Loss of noradrenergic afferents is observed in the neocortex and hippocampal CA1 subfield in 24-month-old AppNL-G-F/NL-G-F mice. Brain sections were immunostained with anti-norepinephrine transporter (green) and anti-amyloid-β (magenta). From Sakakibara et al., JAD82(4).

Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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Voxel-wise ICC maps show that the reproducibility of longitudinal gray matter volume changes determined by VBM between non-accelerated and accelerated MRI is good to excellent for many regions but may vary between diseases and regions. From Takao et al., JAD83(1).

This book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI 

Paclitaxel (PTX) reduces phosphorylated tau and reactive gliosis in 3xTg-AD mice. Top panels: Staining for GFAP in astrocytes, showed that PTX reduced GFAP expression. Bottom panels: PTX reduced the number of phospho-tau positive neurons in the CA-1. From Cross et al., JAD83(1).

First signs of cognitive decline in Alzheimer's disease can be attributed to bilateral posterior ventrolateral thalamic (purple) and pallidal (blue) grey matter loss (red) in a large sample of individuals with early mild cognitive impairment. From van de Mortel, JAD83(2).

JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT

3D, 3-channel STED microscopy was performed to visualize amyloid precursor protein fragments in early endosomes in hippocampal neurons. A schematics summarizing how an early endosome sorts APP-CTF and APP-NTF into different vesicles is shown to the right. Yu et al., JAD83(2).

JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content

Aβ accumulates in leptomeningeal and penetrating arteries in Tg-ArcSwe. Texas red-labeled vessels in the cerebral cortex while Methoxy-X04 (Cyan) labeled Aβ-fibrils. EM micrographs show leptomeningeal artery with Aβ (gold particles) in smooth muscle cell. From Skaaraas et al., JAD82(4).

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