MoreiraJournal of Alzheimer's Diseasecircuits2023 Alzheimer AwardpRhoAAIAD Vol.9 (microbiome)tractographyCOVID-19 contentnCHOJAD Reports (updated)toothlossChrm1

New Co-Editor-in-Chief Appointed:
Paula I. Moreira, PhD, is an Associate Professor of Physiology and leads the Mitochondria in Brain Disorders research group at the Center for Neuroscience and Cell Biology at the University of Coimbra.

Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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Six spatiotemporal perfusion circuits were identified based on the differences in the arterial transit time values for 12 neuropsychiatric sub-symptoms in patients with Alzheimer's disease performed the pseudo-continuous arterial spin labeling among brain regions. From Jiang et al., JAD95(3).

The 2023 Alzheimer's Award goes to Henning Tiemeier, MD, PhD, and Rosanne Freak-Poli, PhD, as co-authors of this winning paper, which presents important insights into the impact of poor social health, specifically loneliness, on cognitive decline and the risk of dementia in older adults.

The expression of pRhoA at S188 in the hippocampus and cortex is dependent on the stereotactic plane. pRhoA expression decreased in the rostral regions (Plane 2) but increased in the caudal regions corresponding to Plane 4. From Nik Akhtar and Lu, JAD 95(4).

Edited by Giulio M. Pasinetti, this book (AIAD Vol.9) is a compilation of work by researchers intent on exploring the complex role of the gut microbiome in Alzheimer’s disease.

Exploring the association between posttraumatic stress disorder, traumatic brain injury, and vulnerability to Alzheimer's disease. Manual tractography was applied in male veterans to investigate the white matter microstructure of three fiber tracts. From Marcolini et al., JAD95(4).

COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19

Patients with AD were divided into two groups based on a 130 g/day net carbohydrate (nCHO) cutoff. Results comparing lower-higher nCHO groups suggest that restricting carbohydrates may reduce atrophy in sensorimotor and visual cortex. From Bramen et al., JAD96(1).

JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content

Tau PET tracer retention quantified as standardized uptake ratio (SUVR) was elevated in the limbic and neocortical areas of AD patients and was further increased in the pons, including the locus coeruleus, of the patients with marked tooth loss (arrowhead). From Matsumoto et al., JAD96(3).

Cholinergic Receptor Muscarinic 1 (Chrm1) colocalizes and comigrates with mitochondria in cultured sensory neurons. Chrm1 deleted mice exhibit mitochondrial defects in sensory neurons, potentially associated with peripheral sensory loss in Alzheimer's. From Sabbir, JAD 98(1).

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