Upcoming Supplementary Issue:Omics Approaches in Alzheimer's Disease Research (Guest Editor: Sudeshna Das). Click the visual for details in the Calls for Papers (PDF) (opens in a new tab). Submission deadline: July 31, 2023
G) A compact plaque double stained with anti-Aβ antibody W02 (red) and DAPI with 0.3% Sudan Black pretreatment to remove autofluorescence. H) The compact Aβ (arrows) remains DAPI-positive despite pretreatment, showing that DAPI stains compact plaques. From Mabrouk et al., JAD88(3).
Edited by Giulio M. Pasinetti, this book (AIAD Vol.9) is a compilation of work by researchers intent on exploring the complex role of the gut microbiome in Alzheimer’s disease. For details & to order, click the image or go here
Quiescent HSV-1 is reactivated by VZV infection to cause AD. (A) VCV-induced quiescence of HSV-1 shown by expression of LAT. VZV infection after HSV-1 latency confirmed by qPCR. HSV and VZV (B) and Aβ and TUJ1 expression (C) detected via immunostaining. From Cairns et al., JAD88(3).
The 2022 Alzheimer Award goes to Yonas E. Geda, MD, and Janina Krell-Roesch, PhD, as co-authors of the winning JAD paper that presents important findings on the impact of physical activity on cognitive change in older adults. For details, go to: j-alz.com/award
A 25-year-old patient experienced an extremely early onset of bvFTD with frontal-temporal atrophy on T1 and hypometabolism on FDG-PET, however, no Aβ and tau protein deposition was found on AV45 and PI2620 PET. From Chu et al., JAD90(3).
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
LATEST JAD EDITORS’ BLOG Familiar Music May Help Caregivers and Loved Ones Living with Dementia to Connect with One Another by Aaron Colverson
Analysis of multi-shell DW-MRI reveals significant effects of disease stage on diffusion-derived measures of tissue integrity. Specific WM tracts show decreased apparent fiber density (AFD) and fiber bundle cross-section (FC). From Giraldo et al., JAD90(4).
This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here
p-tau181-positive axons overlap with parvalbumin-expressing interneurons with disrupted myelin sheets in APPNLGF. Brains were stained with antibodies against parvalbumin (magenta), p-tau181 (green), myelin basic protein (cyan) and FSB for Aβ plaques (blue). From Hirota et al., JAD93(3).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
A new model of tau pathology spread in the medial temporal lobe according to the adult neurogenesis theory of Alzheimer's disease. DG, dentate gyrus; EC, entorhinal cortex; TEC, trans-entorhinal cortex; CA, cornu ammonis. From Abbate, JAD93(4).