The 2023 Alzheimer's Award goes to Henning Tiemeier, MD, PhD, and Rosanne Freak-Poli, PhD, as co-authors of this winning paper, which presents important insights into the impact of poor social health, specifically loneliness, on cognitive decline and the risk of dementia in older adults.
p-tau181-positive axons overlap with parvalbumin-expressing interneurons with disrupted myelin sheets in APPNLGF. Brains were stained with antibodies against parvalbumin (magenta), p-tau181 (green), myelin basic protein (cyan) and FSB for Aβ plaques (blue). From Hirota et al., JAD93(3).
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
A new model of tau pathology spread in the medial temporal lobe according to the adult neurogenesis theory of Alzheimer's disease. DG, dentate gyrus; EC, entorhinal cortex; TEC, trans-entorhinal cortex; CA, cornu ammonis. From Abbate, JAD93(4).
Edited by Giulio M. Pasinetti, this book (AIAD Vol.9) is a compilation of work by researchers intent on exploring the complex role of the gut microbiome in Alzheimer’s disease.
Localization of axon initial segment (TRIM46, magenta) astrocytes (glial fibrillary acidic protein; GFAP, yellow), somatodendritic compartment (MAP2, cyan), and nuclei (Hoechst, blue) in primary wild type mouse cortical neuron cultures. From Best et al., JAD93(4).
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
FKBP52 is decreased at asymptomatic stages of the neurodegenerative process in rare neurons exhibiting deposits of the early Tau P422 isoform, both in the frontal cortex of Braak IV Alzheimer’s patients and spinal cord of 1-month-old P301S mice. From Meduri et al., JAD94(1).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
A subset of microglia (purple) in a mouse model of tauopathy showed features of senescence, and was characterized by Ccl4+ staining (white). From Ng et al., JAD95(2).
Complexity of fMRI timeseries is an index of information processing capacity and is reduced in patients with Alzheimer’s disease as compared to cognitively normal subjects. Decreased complexity is also associated with increased tau deposition. From Jann et al., JAD95(2).