is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19

LATEST JAD EDITORS’ BLOG
A Science-Based Falsifiability Test for the Amyloid Hypothesis (AHyp)
by Claudiu Bandea, PhD

TgF344-AD pathology at 18 months. Representative images of NeuN (purple), GFAP (green), Iba-1 (yellow), and Aβ (blue) staining in WT control and TgF344-AD animals illustrating pathology in the hippocampal CA1, CA3, and hilus regions. From Broussard et al., JAD86(4).

This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here

PET imaging of a 43-year-old patient with Capgras syndrome. 18F-FDG PET showed low metabolism in frontal and temporal lobes (a). 11C-PIB-PET showed amyloid deposition is positive (b, c). Both results supported the diagnosis of early-onset Alzheimer’s disease. From Mi et al., JAD87(1).

The 2021 Alzheimer Award goes to Giulio Taglialatela, PhD, and Balaji Krishnan , PhD, as co-authors of the winning JAD paper that explores why certain individuals remain cognitively intact despite changes to the brain normally associated with fully symptomatic AD. For details, go to: j-alz.com/award 

pTau protein, detected through anti-S396, was found accumulating within cells from the hippocampus in very young rTg4510 mice (A – F). pTau at sites labeled by AT180 was found coexisting with neurons from cortex (G) and hippocampus (H and H’). From Xolalpa-Cueva et al., JAD87(2).

This book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI 

Evidence for ApoE/Reelin-ApoER2 axis disruption in the entorhinal-hippocampal memory system in AD. ApoE, HNE-ApoE, Reelin, ApoER2, Dab1, and p-Tau accumulate in neuritic plaques in the molecular layers of the dentate gyrus (A-C) and cornu ammonis (D-F). From Ramsden et al., JAD87(3).

JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT

A gut neuroepithelial circuit activation (the neuropod cells) in response to bacterial curli breach in the symptomatic AD mice. TLR2, Toll-Like Receptor 2; Aβ, amyloid-beta; PGP 9.5, Protein gene product 9.5 (neuroendocrine marker). From Das et al., JAD 88(1).

JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content

Amyloid-β deposition in the olfactory pathway of WT and App-KI mice: olfactory bulb (OB), anterior olfactory nucleus (AOL), olfactory tubercle (OT), piriform cortex (PC), amygdala (Amg), and entorhinal cortex (EC). From Narukawa et al., JAD88(1).