COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
The 2021 Alzheimer Award goes to Giulio Taglialatela, PhD, and Balaji Krishnan , PhD, as co-authors of the winning JAD paper that explores why certain individuals remain cognitively intact despite changes to the brain normally associated with fully symptomatic AD. For details, go to: j-alz.com/award
Neuritic plaque (left) and neurofibrillary tangle (right): characteristic lesions of a brain with Alzheimer's disease. Images taken with confocal microscope (SP8, Leica). From Pacheco-Herrero et al., JAD84(3).
This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here
PET images of a cognitively unimpaired participant. Amyloid scans were visually negative (A−), with only age-expected off-target WM binding. Tau scans showed atypical suprathreshold (T+), asymmetric (L>R) signal that rose over five years. From Schwarz et al., JAD85(1).
LATEST JAD EDITORS’ BLOG What is the Purpose of Medicine When Dealing with Incurable Alzheimer’s Disease? by Jack de la Torre, MD, PhD
VAMP3 (green) and NGF (red) immunofluorescent co-localization analysis from astrocytes in neuron-astrocyte co-cultures. From Song et al., JAD85(1).
This book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
Correlation between Diffusion Tensor Imaging measures in the superficial white matter and CSF amyloid-β level. From Contarino et al., JAD85(1).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
Peptidylarginine deiminases (PADs) have a N terminal immunoglobin-like domain and a C-terminal catalytic domain, and contains five Ca2+ binding sites. The activity of PAD enzymes is regulated by the binding of calcium. From Wang et al., JAD85(2).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
PET and MRI images of patients with very early onset AD caused by PSEN1 mutations. The amyloid and tau PET of both patients showed amyloid and tau deposition. FDG-PET and MRI revealed hypometabolism and atrophy in the whole cerebral cortices. From Chen et al., JAD85(1).