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C. Liu, Lee, S. H., Loewenstein, D. A., Galvin, J. E., Levin, B. E., McKinney, A., and Alperin, N., “Early Amnestic Mild Cognitive Impairment Is Associated with Reduced Total Cerebral Blood Flow with no Brain Tissue Loss.”, J Alzheimers Dis, vol. 91, no. 4, pp. 1313-1322, 2023.
J. Paulo Alme Santos, Vizuete, A., Hansen, F., Biasibetti, R., and Gonçalves, C. - A., “Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 1, pp. 237-249, 2018.
C. Lanzillotta, Tramutola, A., Meier, S., Schmitt, F., Barone, E., Perluigi, M., Di Domenico, F., and Abisambra, J. F., “Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.”, J Alzheimers Dis, vol. 62, no. 1, pp. 347-359, 2018.
B. Portal, Södergren, M., Borrell, T. Parés I., Giraud, R., Metzendorf, N. G., Hultqvist, G., Nilsson, P., and Lindskog, M., “Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the AppNL-F Mouse Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 100, no. 3, pp. 1017-1037, 2024.
F. Zhang, Wei, J., Li, X., Ma, C., and Gao, Y., “Early Candidate Urine Biomarkers for Detecting Alzheimer's Disease Before Amyloid-β Plaque Deposition in an APP (swe)/PSEN1dE9 Transgenic Mouse Model.”, J Alzheimers Dis, vol. 66, no. 2, pp. 613-637, 2018.
A. Marseglia, Fratiglioni, L., Laukka, E. J., Santoni, G., Pedersen, N. L., Bäckman, L., and Xu, W., “Early Cognitive Deficits in Type 2 Diabetes: A Population-Based Study.”, J Alzheimers Dis, vol. 53, no. 3, pp. 1069-78, 2016.
N. Acosta-Baena, Lopera-Gómez, C. M., Jaramillo-Elorza, M. C., Velilla-Jiménez, L., Villegas-Lanau, C. Andrés, Sepúlveda-Falla, D., Arcos-Burgos, M., and Lopera, F., “Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant AD”, J Alzheimers Dis, vol. 92, no. 3, pp. 911-923, 2023.
P. Heymann, Gienger, R., Hett, A., Müller, S., Laske, C., Robens, S., Ostermann, T., and Elbing, U., “Early Detection of Alzheimer's Disease Based on the Patient's Creative Drawing Process: First Results with a Novel Neuropsychological Testing Method.”, J Alzheimers Dis, vol. 63, no. 2, pp. 675-687, 2018.
A. Tort-Merino, Valech, N., Peñaloza, C., Grönholm-Nyman, P., León, M., Olives, J., Estanga, A., Ecay-Torres, M., Fortea, J., Martínez-Lage, P., Molinuevo, J. L., Laine, M., Rodríguez-Fornells, A., and Rami, L., “Early Detection of Learning Difficulties when Confronted with Novel Information in Preclinical Alzheimer's Disease Stage 1.”, J Alzheimers Dis, vol. 58, no. 3, pp. 855-870, 2017.
W. Chen, Lin, C., Su, F., Fang, Y., Liu, G., Chen, Y. - C., Zhou, X., Yao, X., Ashford, C. B., Li, F., J Ashford, W., Fu, Q., and Pei, Z., “Early Diagnosis of Mild Cognitive Impairment due to Alzheimer's Disease Using a Composite of MemTrax and Blood Biomarkers.”, J Alzheimers Dis, vol. 94, no. 3, pp. 1093-1103, 2023.
J. Bourgin, Guyader, N., Chauvin, A., Juphard, A., Sauvée, M., Moreaud, O., Silvert, L., and Hot, P., “Early Emotional Attention is Impacted in Alzheimer's Disease: An Eye-Tracking Study.”, J Alzheimers Dis, vol. 63, no. 4, pp. 1445-1458, 2018.
C. M. Dengler-Crish, Smith, M. A., and Wilson, G. N., “Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 55, no. 4, pp. 1605-1619, 2017.
I. Zaletel, Schwirtlich, M., Perović, M., Jovanović, M., Stevanović, M., Kanazir, S., and Puškaš, N., “Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors.”, J Alzheimers Dis, vol. 65, no. 3, pp. 963-976, 2018.
Z. Rusznák, Kim, W. Scott, Hsiao, J. - H. T., Halliday, G. M., Paxinos, G., and Fu, Y. H., “Early in vivo Effects of the Human Mutant Amyloid-β Protein Precursor (hAβPPSwInd) on the Mouse Olfactory Bulb.”, J Alzheimers Dis, vol. 49, no. 2, pp. 443-57, 2016.
C. P. Hutton, Lemon, J. A., Sakic, B., C Rollo, D., Boreham, D. R., Fahnestock, M., J Wojtowicz, M., and Becker, S., “Early Intervention with a Multi-Ingredient Dietary Supplement Improves Mood and Spatial Memory in a Triple Transgenic Mouse Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 64, no. 3, pp. 835-857, 2018.
N. Brosens, Samouil, D., Stolker, S., Katsika, E. Vasilina, Weggen, S., Lucassen, P. J., and Krugers, H. J., “Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice.”, J Alzheimers Dis, vol. 96, no. 3, pp. 1097-1113, 2023.
K. Kantarci, Lowe, V. J., Lesnick, T. G., Tosakulwong, N., Bailey, K. R., Fields, J. A., Shuster, L. T., Zuk, S. M., Senjem, M. L., Mielke, M. M., Gleason, C., Jack, C. R., Rocca, W. A., and Miller, V. M., “Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition.”, J Alzheimers Dis, vol. 53, no. 2, pp. 547-56, 2016.
B. Gurel, Cansev, M., Sevinc, C., Kelestemur, S., Ocalan, B., Cakir, A., Aydin, S., Kahveci, N., Ozansoy, M., Taskapilioglu, O., Ulus, I. Hakki, Başar, M. Karayel, Sahin, B., Tuzuner, M. Bora, and Baykal, A. Tarik, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer's Disease Mouse Model.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1399-1410, 2018.
L. Xie, Das, S. R., Wisse, L. E. M., Ittyerah, R., Yushkevich, P. A., and Wolk, D. A., “Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex.”, J Alzheimers Dis, vol. 62, no. 1, pp. 85-92, 2018.
A. M. Masoud, Bihaqi, S. W., Machan, J. T., Zawia, N. H., and Renehan, W. E., “Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1257-64, 2016.
S. M. de la Monte, Tong, M., Daiello, L. A., and Ott, B. R., “Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.”, J Alzheimers Dis, vol. 68, no. 2, pp. 657-668, 2019.
B. Michalowsky, Thyrian, J. René, Eichler, T., Hertel, J., Wucherer, D., Flessa, S., and Hoffmann, W., “Economic Analysis of Formal Care, Informal Care, and Productivity Losses in Primary Care Patients who Screened Positive for Dementia in Germany.”, J Alzheimers Dis, vol. 50, no. 1, pp. 47-59, 2016.
C. M. Black, Fillit, H., Xie, L., Hu, X., M Kariburyo, F., Ambegaonkar, B. M., Baser, O., Yuce, H., and Khandker, R. K., “Economic Burden, Mortality, and Institutionalization in Patients Newly Diagnosed with Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 1, pp. 185-193, 2018.
S. Ikeda, Mimura, M., Ikeda, M., Wada-Isoe, K., Azuma, M., Inoue, S., and Tomita, K., “Economic Burden of Alzheimer's Disease Dementia in Japan.”, J Alzheimers Dis, vol. 81, no. 1, pp. 309-319, 2021.
J. M. J. Vonk, Rentería, M. Arce, Medina, V. M., Pericak-Vance, M. A., Byrd, G. S., Haines, J., Brickman, A. M., and Manly, J. J., “Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.”, J Alzheimers Dis, vol. 72, no. 2, pp. 495-506, 2019.

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