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Neuropsychological Tests
S. Vijayaraghavan, Darreh-Shori, T., Rongve, A., Berge, G., Sando, S. B., White, L. R., Auestad, B. H., Witoelar, A., Andreassen, O. A., Ulstein, I. D., and Aarsland, D., “Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease.”, J Alzheimers Dis, vol. 50, no. 2, pp. 567-76, 2016.
C. Rattanabannakit, Risacher, S. L., Gao, S., Lane, K. A., Brown, S. A., McDonald, B. C., Unverzagt, F. W., Apostolova, L. G., Saykin, A. J., and Farlow, M. R., “The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1145-55, 2016.
C. E. Gleason, Norton, D., Anderson, E. D., Wahoske, M., Washington, D. T., Umucu, E., Koscik, R. L., N Dowling, M., Johnson, S. C., Carlsson, C. M., and Asthana, S., “Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker.”, J Alzheimers Dis, vol. 61, no. 1, pp. 79-89, 2018.
Nigeria
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
Oxidative Stress
T. Kondo, Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S. - I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., and Inoue, H., “Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.”, Cell Stem Cell, vol. 12, no. 4, pp. 487-96, 2013.
Parabiosis
S. A. Villeda, Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., Wabl, R., Udeochu, J., Wheatley, E. G., Zou, B., Simmons, D. A., Xie, X. S., Longo, F. M., and Wyss-Coray, T., “Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.”, Nat Med, vol. 20, no. 6, pp. 659-63, 2014.
Peptide Fragments
N. Lelental, Brandner, S., Kofanova, O., Blennow, K., Zetterberg, H., Andreasson, U., Engelborghs, S., Mroczko, B., Gabryelewicz, T., Teunissen, C., Mollenhauer, B., Parnetti, L., Chiasserini, D., Molinuevo, J. Luis, Perret-Liaudet, A., Verbeek, M. M., Andreasen, N., Brosseron, F., Bahl, J. M. C., Herukka, S. - K., Hausner, L., Frölich, L., Labonte, A., Poirier, J., Miller, A. - M., Zilka, N., Kovacech, B., Urbani, A., Suardi, S., Oliveira, C., Baldeiras, I., Dubois, B., Rot, U., Lehmann, S., Skinningsrud, A., Betsou, F., Wiltfang, J., Gkatzima, O., Winblad, B., Buchfelder, M., Kornhuber, J., and Lewczuk, P., “Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics.”, J Alzheimers Dis, vol. 52, no. 1, pp. 51-64, 2016.
C. E. Gleason, Norton, D., Anderson, E. D., Wahoske, M., Washington, D. T., Umucu, E., Koscik, R. L., N Dowling, M., Johnson, S. C., Carlsson, C. M., and Asthana, S., “Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker.”, J Alzheimers Dis, vol. 61, no. 1, pp. 79-89, 2018.
Perception
C. Rattanabannakit, Risacher, S. L., Gao, S., Lane, K. A., Brown, S. A., McDonald, B. C., Unverzagt, F. W., Apostolova, L. G., Saykin, A. J., and Farlow, M. R., “The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1145-55, 2016.
Phenotype
T. Kondo, Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S. - I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., and Inoue, H., “Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.”, Cell Stem Cell, vol. 12, no. 4, pp. 487-96, 2013.
Polymerase Chain Reaction
S. A. Villeda, Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., Wabl, R., Udeochu, J., Wheatley, E. G., Zou, B., Simmons, D. A., Xie, X. S., Longo, F. M., and Wyss-Coray, T., “Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.”, Nat Med, vol. 20, no. 6, pp. 659-63, 2014.
Presenilin-1
Y. Hasegawa, Toyama, K., Uekawa, K., Ichijo, H., and Kim-Mitsuyama, S., “Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.”, J Alzheimers Dis, vol. 61, no. 1, pp. 259-263, 2018.
Prospective Studies
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
E. Kuźma, Soni, M., Littlejohns, T. J., Ranson, J. M., van Schoor, N. M., Deeg, D. J. H., Comijs, H., Chaves, P. H. M., Kestenbaum, B. R., Kuller, L. H., Lopez, O. L., Becker, J. T., Langa, K. M., Henley, W. E., Lang, I. A., Ukoumunne, O. C., and Llewellyn, D. J., “Vitamin D and Memory Decline: Two Population-Based Prospective Studies.”, J Alzheimers Dis, vol. 50, no. 4, pp. 1099-108, 2016.
Protein Structure, Quaternary
T. Kondo, Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S. - I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., and Inoue, H., “Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.”, Cell Stem Cell, vol. 12, no. 4, pp. 487-96, 2013.
Proteomics
B. Gurel, Cansev, M., Sevinc, C., Kelestemur, S., Ocalan, B., Cakir, A., Aydin, S., Kahveci, N., Ozansoy, M., Taskapilioglu, O., Ulus, I. Hakki, Başar, M. Karayel, Sahin, B., Tuzuner, M. Bora, and Baykal, A. Tarik, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer's Disease Mouse Model.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1399-1410, 2018.
Quality Control
N. Lelental, Brandner, S., Kofanova, O., Blennow, K., Zetterberg, H., Andreasson, U., Engelborghs, S., Mroczko, B., Gabryelewicz, T., Teunissen, C., Mollenhauer, B., Parnetti, L., Chiasserini, D., Molinuevo, J. Luis, Perret-Liaudet, A., Verbeek, M. M., Andreasen, N., Brosseron, F., Bahl, J. M. C., Herukka, S. - K., Hausner, L., Frölich, L., Labonte, A., Poirier, J., Miller, A. - M., Zilka, N., Kovacech, B., Urbani, A., Suardi, S., Oliveira, C., Baldeiras, I., Dubois, B., Rot, U., Lehmann, S., Skinningsrud, A., Betsou, F., Wiltfang, J., Gkatzima, O., Winblad, B., Buchfelder, M., Kornhuber, J., and Lewczuk, P., “Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics.”, J Alzheimers Dis, vol. 52, no. 1, pp. 51-64, 2016.
Rats
R. Pluta, Kocki, J., Ułamek-Kozioł, M., Petniak, A., Gil-Kulik, P., Januszewski, S., Bogucki, J., Jabłoński, M., Brzozowska, J., Furmaga-Jabłońska, W., Bogucka-Kocka, A., and Czuczwar, S. J., “Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1023-31, 2016.
Rats, Wistar
R. Pluta, Kocki, J., Ułamek-Kozioł, M., Petniak, A., Gil-Kulik, P., Januszewski, S., Bogucki, J., Jabłoński, M., Brzozowska, J., Furmaga-Jabłońska, W., Bogucka-Kocka, A., and Czuczwar, S. J., “Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1023-31, 2016.
Reaction Time
Y. Hasegawa, Toyama, K., Uekawa, K., Ichijo, H., and Kim-Mitsuyama, S., “Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.”, J Alzheimers Dis, vol. 61, no. 1, pp. 259-263, 2018.
A. Suzuki, Shinozaki, J., Yazawa, S., Ueki, Y., Matsukawa, N., Shimohama, S., and Nagamine, T., “Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1653-1665, 2018.
Reference Standards
N. Lelental, Brandner, S., Kofanova, O., Blennow, K., Zetterberg, H., Andreasson, U., Engelborghs, S., Mroczko, B., Gabryelewicz, T., Teunissen, C., Mollenhauer, B., Parnetti, L., Chiasserini, D., Molinuevo, J. Luis, Perret-Liaudet, A., Verbeek, M. M., Andreasen, N., Brosseron, F., Bahl, J. M. C., Herukka, S. - K., Hausner, L., Frölich, L., Labonte, A., Poirier, J., Miller, A. - M., Zilka, N., Kovacech, B., Urbani, A., Suardi, S., Oliveira, C., Baldeiras, I., Dubois, B., Rot, U., Lehmann, S., Skinningsrud, A., Betsou, F., Wiltfang, J., Gkatzima, O., Winblad, B., Buchfelder, M., Kornhuber, J., and Lewczuk, P., “Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics.”, J Alzheimers Dis, vol. 52, no. 1, pp. 51-64, 2016.
Reproducibility of Results
A. D. Dekker, Ulgiati, A. M., Groen, H., Boxelaar, V. A., Sacco, S., Falquero, S., Carfi, A., di Paola, A., Benejam, B., Valldeneu, S., Fopma, R., Oosterik, M., Hermelink, M., Beugelsdijk, G., Schippers, M., Henstra, H., Scholten-Kuiper, M., Willink-Vos, J., de Ruiter, L., Willems, L., de Jong, A. Loonstra-, Coppus, A. M. W., Tollenaere, M., Fortea, J., Onder, G., Rebillat, A. - S., Van Dam, D., and De Deyn, P. P., “The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation.”, J Alzheimers Dis, vol. 81, no. 4, pp. 1505-1527, 2021.
ROC Curve
A. Suzuki, Shinozaki, J., Yazawa, S., Ueki, Y., Matsukawa, N., Shimohama, S., and Nagamine, T., “Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1653-1665, 2018.
Self Report
C. Rattanabannakit, Risacher, S. L., Gao, S., Lane, K. A., Brown, S. A., McDonald, B. C., Unverzagt, F. W., Apostolova, L. G., Saykin, A. J., and Farlow, M. R., “The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1145-55, 2016.

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