A Century of Scientific and Clinical Research: Table of Contents

Alzheimer’s Disease: A Century of Scientific and Clinical Research ("Alzheimer 100")
A Special Issue of JAD

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Historical Perspective

Pages 5-13 
Jesse F. Ballenger
Progress in the history of Alzheimer's disease: The importance of context

Pages 15-26 
José Manuel Martínez Lage
100 Years of Alzheimer's disease (1906-2006)



Pages 29-33 
Melvyn J. Ball
The essential lesion of Alzheimer disease: A surprise in retrospect

Pages 35-44 
Heiko Braak, Udo Rüb, Christian Schultz, Kelly Del Tredici
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases

Pages 45-52 
Bernardino Ghetti
Neurodegeneration and hereditary dementias: 40 years of learning

Pages 53-60 
Asao Hirano and Maki Iida
Topographic study of Alzheimer's neurofibrillary changes: A personal perspective

Pages 61-70 
Kurt A. Jellinger
Clinicopathological analysis of dementia disorders in the elderly - An update

Pages 71-75 
Michael. Kidd
The history of the paired helical filaments


Synaptic Changes

Pages 79-89 
M.M. Esiri and S.A. Chance
Vulnerability to Alzheimer's pathology in neocortex: The roles of plasticity and columnar organization

Pages 91-99 
Eliezer Masliah, Leslie Crews, Lawrence Hansen
Synaptic remodeling during aging and in Alzheimer's disease

Pages 101-115 
Stephen W. Scheff and Douglas A. Price
Alzheimer's disease-related alterations in synaptic density: Neocortex and hippocampus

Pages 117-119 
Robert D. Terry
My own experience in early research on Alzheimer disease



Pages 123-126 
Karen H. Ashe
Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease

Pages 127-132 
Massimo Tabaton and Pierluigi Gambetti
Soluble amyloid-β in the brain: The scarlet pimpernel

Pages 133-149 
Dora Games, Manuel Buttini, Dione Kobayashi, Dale Schenk, Peter Seubert
Mice as models: Transgenic approaches and Alzheimer's disease

Pages 151-153 
John Hardy
Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal

Pages 155-161 
Colin L. Masters and Konrad Beyreuther
Pathways to the discovery of the Aβ amyloid of Alzheimer's disease

Pages 163-168 
Dennis J. Selkoe
Amyloid β-peptide is produced by cultured cells during normal metabolism: A reprise



Pages 171-175 
Jesús Avila
Tau protein, the main component of paired helical filaments

Pages 177-185 
Jean-Pierre Brion
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease

Pages 187-194 
André Delacourte
The natural and molecular history of Alzheimer's disease

Pages 195-207 
Michel Goedert, Aaron Klug, R. Anthony Crowther
Tau protein, the paired helical filament and Alzheimer's disease

Pages 209-217 
Yasuo Ihara
Neurofibrillary tangles/paired helical filaments (1981-83)

Pages 219-242 
Khalid Iqbal and Inge Grundke-Iqbal
Discoveries of Tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: A personal historical perspective

Pages 243-250 
Gail V.W. Johnson
Tau phosphorylation and proteolysis: Insights and perspectives

Pages 251-256 
Kenneth S. Kosik
Traveling the tau pathway: A personal account

Pages 257-262 
Virginia M.-Y. Lee and John Q. Trojanowski
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now


Disease Mechanisms

Pages 265-269 
Peter Davies
A long trek down the pathways of cell death in Alzheimer's disease

Pages 271-276 
Patrick L. McGeer, Joseph Rogers, Edith G. McGeer
Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years

Pages 277-289 
Ralph A. Nixon and Anne M. Cataldo
Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease

Pages 291-300 
Daniel P. Perl and Sharon Moalem
Aluminum and Alzheimer's disease, a personal perspective after 25 years

Pages 301-304 
George Perry
Solving the insoluble

Pages 305-308 
Mark A. Smith
Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss!

Pages 309-317 
Akihiko Takashima
GSK-3 is essential in the pathogenesis of Alzheimer's disease

Pages 319-325 
F.W. van Leeuwen, E.M. Hol, D.F. Fischer
Frameshift proteins in Alzheimer's disease and in other conformational disorders: Time for the ubiquitin-proteasome system



Pages 329-339 
Efrat Levy, Frances Prelli, Blas Frangione
Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variant

Pages 341-347 
Alison Goate
Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer's disease

Pages 349-360 
Dmitry Goldgaber
My story: The discovery and mapping to chromosome 21 of the Alzheimer amyloid gene

Pages 361-366 
Allen D. Roses
On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease

Pages 367-372 
Gerard D. Schellenberg
Early Alzheimer's disease genetics

Pages 373-380 
Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghetti
Mutations in the tau gene (MAPT) in FTDP-17: The family with Multiple System Tauopathy with Presenile Dementia (MSTD)

Pages 381-387 
Ekaterina Rogaeva, Toshitaka Kawarai, Peter St George-Hyslop
Genetic complexity of Alzheimer's disease: Successes and challenges

Pages 389-398 
Christine Van Broeckhoven and Samir Kumar-Singh
Genetics and pathology of alpha-secretase site AβPP mutations in the understanding of Alzheimer's disease


Diagnosis and Treatment

Pages 401-407 
Jesse Skoch, Bradley T. Hyman, Brian J. Bacskai
Preclinical characterization of amyloid imaging probes with multiphoton microscopy

Pages 409-415 
Zaven S. Khachaturian
Diagnosis of Alzheimer's disease: Two-decades of progress

Pages 417-423 
Ian G. McKeith 
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop

Pages 425-432 
Dave Morgan
Immunotherapy for Alzheimer's disease

Pages 433-438 
Beka Solomon
Alzheimer's disease immunotherapy: From in vitro amyloid immunomodulation to in vivo vaccination

Pages 439-445 
William K. Summers
Tacrine, and Alzheimer's treatments

Pages 447-453
Peter J. Whitehouse
Quality of life: The bridge from the cholinergic basal forebrain to cognitive science and bioethics