Alzheimer’s Disease: A Century of Scientific and Clinical Research ("Alzheimer 100")
A Special Issue of JAD
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Historical Perspective
Pages 5-13
Jesse F. Ballenger
Progress in the history of Alzheimer's disease: The importance of context
Pages 15-26
José Manuel Martínez Lage
100 Years of Alzheimer's disease (1906-2006)
Neuropathology
Pages 29-33
Melvyn J. Ball
The essential lesion of Alzheimer disease: A surprise in retrospect
Pages 35-44
Heiko Braak, Udo Rüb, Christian Schultz, Kelly Del Tredici
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases
Pages 45-52
Bernardino Ghetti
Neurodegeneration and hereditary dementias: 40 years of learning
Pages 53-60
Asao Hirano and Maki Iida
Topographic study of Alzheimer's neurofibrillary changes: A personal perspective
Pages 61-70
Kurt A. Jellinger
Clinicopathological analysis of dementia disorders in the elderly - An update
Pages 71-75
Michael. Kidd
The history of the paired helical filaments
Synaptic Changes
Pages 79-89
M.M. Esiri and S.A. Chance
Vulnerability to Alzheimer's pathology in neocortex: The roles of plasticity and columnar organization
Pages 91-99
Eliezer Masliah, Leslie Crews, Lawrence Hansen
Synaptic remodeling during aging and in Alzheimer's disease
Pages 101-115
Stephen W. Scheff and Douglas A. Price
Alzheimer's disease-related alterations in synaptic density: Neocortex and hippocampus
Pages 117-119
Robert D. Terry
My own experience in early research on Alzheimer disease
Amyloid
Pages 123-126
Karen H. Ashe
Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease
Pages 127-132
Massimo Tabaton and Pierluigi Gambetti
Soluble amyloid-β in the brain: The scarlet pimpernel
Pages 133-149
Dora Games, Manuel Buttini, Dione Kobayashi, Dale Schenk, Peter Seubert
Mice as models: Transgenic approaches and Alzheimer's disease
Pages 151-153
John Hardy
Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal
Pages 155-161
Colin L. Masters and Konrad Beyreuther
Pathways to the discovery of the Aβ amyloid of Alzheimer's disease
Pages 163-168
Dennis J. Selkoe
Amyloid β-peptide is produced by cultured cells during normal metabolism: A reprise
Tau
Pages 171-175
Jesús Avila
Tau protein, the main component of paired helical filaments
Pages 177-185
Jean-Pierre Brion
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease
Pages 187-194
André Delacourte
The natural and molecular history of Alzheimer's disease
Pages 195-207
Michel Goedert, Aaron Klug, R. Anthony Crowther
Tau protein, the paired helical filament and Alzheimer's disease
Pages 209-217
Yasuo Ihara
Neurofibrillary tangles/paired helical filaments (1981-83)
Pages 219-242
Khalid Iqbal and Inge Grundke-Iqbal
Discoveries of Tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: A personal historical perspective
Pages 243-250
Gail V.W. Johnson
Tau phosphorylation and proteolysis: Insights and perspectives
Pages 251-256
Kenneth S. Kosik
Traveling the tau pathway: A personal account
Pages 257-262
Virginia M.-Y. Lee and John Q. Trojanowski
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now
Disease Mechanisms
Pages 265-269
Peter Davies
A long trek down the pathways of cell death in Alzheimer's disease
Pages 271-276
Patrick L. McGeer, Joseph Rogers, Edith G. McGeer
Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years
Pages 277-289
Ralph A. Nixon and Anne M. Cataldo
Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease
Pages 291-300
Daniel P. Perl and Sharon Moalem
Aluminum and Alzheimer's disease, a personal perspective after 25 years
Pages 301-304
George Perry
Solving the insoluble
Pages 305-308
Mark A. Smith
Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss!
Pages 309-317
Akihiko Takashima
GSK-3 is essential in the pathogenesis of Alzheimer's disease
Pages 319-325
F.W. van Leeuwen, E.M. Hol, D.F. Fischer
Frameshift proteins in Alzheimer's disease and in other conformational disorders: Time for the ubiquitin-proteasome system
Genetics
Pages 329-339
Efrat Levy, Frances Prelli, Blas Frangione
Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variant
Pages 341-347
Alison Goate
Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer's disease
Pages 349-360
Dmitry Goldgaber
My story: The discovery and mapping to chromosome 21 of the Alzheimer amyloid gene
Pages 361-366
Allen D. Roses
On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease
Pages 367-372
Gerard D. Schellenberg
Early Alzheimer's disease genetics
Pages 373-380
Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghetti
Mutations in the tau gene (MAPT) in FTDP-17: The family with Multiple System Tauopathy with Presenile Dementia (MSTD)
Pages 381-387
Ekaterina Rogaeva, Toshitaka Kawarai, Peter St George-Hyslop
Genetic complexity of Alzheimer's disease: Successes and challenges
Pages 389-398
Christine Van Broeckhoven and Samir Kumar-Singh
Genetics and pathology of alpha-secretase site AβPP mutations in the understanding of Alzheimer's disease
Diagnosis and Treatment
Pages 401-407
Jesse Skoch, Bradley T. Hyman, Brian J. Bacskai
Preclinical characterization of amyloid imaging probes with multiphoton microscopy
Pages 409-415
Zaven S. Khachaturian
Diagnosis of Alzheimer's disease: Two-decades of progress
Pages 417-423
Ian G. McKeith
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop
Pages 425-432
Dave Morgan
Immunotherapy for Alzheimer's disease
Pages 433-438
Beka Solomon
Alzheimer's disease immunotherapy: From in vitro amyloid immunomodulation to in vivo vaccination
Pages 439-445
William K. Summers
Tacrine, and Alzheimer's treatments
Pages 447-453
Peter J. Whitehouse
Quality of life: The bridge from the cholinergic basal forebrain to cognitive science and bioethics
