Thank you sincerely for taking the time to read and acknowledge our research. We are also grateful for your insightful guidance regarding the shortcomings of our study. We have thoroughly reviewed your letter and have reflected deeply on the issues you highlighted in the text. The ADNI database serves as a global specialized cohort for clinical research on Alzheimer's disease, offering a rich array of clinical and biomarker data. The project aimed to focus on the AD pathology and AD clinical performance, which could introduce selection bias and limit the generalizability to other clinical populations. Therefore, the next step is to validate our findings through studies that include more diverse populations. We whole heartedly support the author's proposal for standardizing ATN cutoff values. However, achieving this goal will necessitate collaborative efforts and extensive validation across multiple studies. We eagerly anticipate a future where standardized cutoff values for AD-related biomarkers are more widely available. Due to the absence of a frailty assessment program within the ADNI cohort and the lack of a standardized method for evaluating frailty, we have faced significant challenges in our assessment efforts. To address this, we have turned to the mFI-11 scale as applied by Soon et al. [1] in the ADNI cohort. We are optimistic about achieving a precise evaluation of frailty in this cohort in the future and plan to explore the replication of our findings using various assessment scales. We sincerely appreciate your valuable feedback on our research. Your insights will guide us in enhancing our study in future. Thank you once again.
Bao-Lin Han1, Hui-Fu Wang1,2,*, Lan Tan1,2,*
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China
2Department of Neurology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China
References [1] Soon SXY, Kumar AA, Tan AJL, Lo YT, Lock C, Kumar S, Kwok J, Keong NC (2021) The impact of multimorbidity burden, frailty risk scoring, and 3-directional morphological indices vs. testing for CSF responsiveness in normal pressure hydrocephalus. Front Neurosci 15, 751145.
The investigators did an excellent job studying a 40-year cohort to provide definitive population evidence that oral health is a risk factor for dementia.
Thank you sincerely for taking the time to read and acknowledge our research. We are also grateful for your insightful guidance regarding the shortcomings of our study. We have thoroughly reviewed your letter and have reflected deeply on the issues you highlighted in the text.
The ADNI database serves as a global specialized cohort for clinical research on Alzheimer's disease, offering a rich array of clinical and biomarker data. The project aimed to focus on the AD pathology and AD clinical performance, which could introduce selection bias and limit the generalizability to other clinical populations. Therefore, the next step is to validate our findings through studies that include more diverse populations. We whole heartedly support the author's proposal for standardizing ATN cutoff values. However, achieving this goal will necessitate collaborative efforts and extensive validation across multiple studies. We eagerly anticipate a future where standardized cutoff values for AD-related biomarkers are more widely available. Due to the absence of a frailty assessment program within the ADNI cohort and the lack of a standardized method for evaluating frailty, we have faced significant challenges in our assessment efforts. To address this, we have turned to the mFI-11 scale as applied by Soon et al. [1] in the ADNI cohort. We are optimistic about achieving a precise evaluation of frailty in this cohort in the future and plan to explore the replication of our findings using various assessment scales.
We sincerely appreciate your valuable feedback on our research. Your insights will guide us in enhancing our study in future. Thank you once again.
Bao-Lin Han1, Hui-Fu Wang1,2,*, Lan Tan1,2,*
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China
2Department of Neurology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China
*wanghuifu2010@126.com, dr.tanlan@163.com
References
[1] Soon SXY, Kumar AA, Tan AJL, Lo YT, Lock C, Kumar S, Kwok J, Keong NC (2021) The impact of multimorbidity burden, frailty risk scoring, and 3-directional morphological indices vs. testing for CSF responsiveness in normal pressure hydrocephalus. Front Neurosci 15, 751145.
A very good review about the mitochondrial cascade hypothesis of AD, including a series of aspects.
The investigators did an excellent job studying a 40-year cohort to provide definitive population evidence that oral health is a risk factor for dementia.
It is a research that builds evidence for new perspectives.
I seleted this manuscript
In addition to the huge role of gut dysbiosis, oral dysbiosis is very important factor often overlooked.
It raises the importance of detecting MCI and evaluating oral health so that this factor can be addressed to prevent the development of AD