1 December 2010
The article by Walton  indicated aluminum is instrumental in causing hyperphosphorylation of tau with subsequent development of neurofibrillary tangle formation. Recently tau has been found to mislocalize to dendritic spines causing early synaptic dysfunction . Aluminum mediated hyperphosphorylation of tau may be a trigger for tau dysfunction and abnormal cellular trafficking with mislocalization to dendrites causing synaptic dysfunction, which probably is an early feature of Alzheimer's disease.
Steven R Brenner, MD
St. Louis VA Medical Center and Department of Neurology and Psychiatry at St. Louis University, St. Louis, MO, USA; Email: SBren20979@aol.com
 Walton JR (2010) Evidence for participation of aluminum in neurofibrilllary tangle formation and growth in Alzheimer's disease. J Alzheimers Dis 22, 65-72.
 Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D (2010) Tau mislocalizatoin of dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 68, 1067-1081.