6 December 2021
Sydney, Australia – An international research collaboration has found that high occupational complexity is associated with dementia-free survival time, highlighting the importance of maintaining cognitive stimulation throughout life for lowering the risk of dementia. The collaboration, led by UNSW Sydney’s Centre for Healthy Brain Ageing (CHeBA), analysed 10,195 older adults across seven international studies from the Cohort Studies of Memory in an International Consortium (COSMIC). The study, published in the Journal of Alzheimer’s Disease, found that having at least completed high school and high occupational complexity were both and independently associated with dementia-free survival time, implying a lower chance of having developed dementia before the study ended.
Dementia currently affects more than 50 million people worldwide and although age is the strongest risk factor for developing dementia, dementia is not an inevitable consequence of ageing. Estimates suggest that 40% to 50% of dementia cases may be preventable through intervention of modifiable risk factors, which include such things as midlife hypertension, midlife obesity, depression and physical activity – as well as education.
Study coordinator of COSMIC, Darren Lipnicki, PhD, said that both early life education and mental engagement at work during adulthood are theorised to help prevent late-life dementia, but little is known about similarities or differences across geographical regions.
This study assigned complexity ratings to primary life-time occupations, with jobs requiring more cognitive and mental effort considered more complex – using data from studies across Australia, Germany, Italy, South Korea, Spain, and the USA. The research then examined whether education and occupational complexity were associated with dementia in later life, and whether there were similarities and differences across geographical regions.
Lead author Jinshil Hyun, PhD, in the Department of Neurology of New York’s Albert Einstein College of Medicine, said the findings were fairly consistent across the different countries investigated, though more so for occupational complexity than for education. Interestingly, it seemed that "high school completion" was enough to prevent developing dementia, which suggested a threshold effect. There was no significant difference in dementia rates between "high school completion" and "above high school completion."
Around one quarter of the association between education and dementia was due to occupational complexity, consistent with higher levels of education often leading to more complex occupations. Completing high school was particularly important for promoting occupational complexity and reducing dementia risk in Blacks from the US New York area, but less important in the Sydney, Australia study where low occupational complexity was relatively infrequent.
“This research emphasises the significance of complex mental activity throughout life for reducing the risk of dementia,” said Professor Perminder Sachdev, co-director of UNSW Sydney’s Centre for Healthy Brain Ageing (CHeBA).
NOTES FOR EDITORS
Full study: "Education, Occupational Complexity, and Incident Dementia: A COSMIC Collaborative Cohort Study" by Jinshil Hyun, Charles B. Hall, Mindy J. Katz, Carol A. Derby, Darren M. Lipnicki, John D. Crawford, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Jong Bin Bae, Susanne Röhr, Steffi Riedel-Heller, Mary Ganguli, Erin Jacobsen, Tiffany F. Hughes, Henry Brodaty, Nicole A. Kochan, Julian Trollor, Antonio Lobo, Javier Santabarbara, Raul Lopez-Anton, Perminder S. Sachdev, and Richard B. Lipton for Cohort Studies of Memory in an International Consortium (DOI: 10.3233/JAD-210627), published online in the Journal of Alzheimer's Disease in advance of the publication of Volume 85, Issue 1. The article is available online at: content.iospress.com/articles/journal-of-alzheimers-disease/jad210627.
About UNSW Sydney’s Centre for Healthy Brain Ageing
Established in 2012, the Cohort Studies of Memory in an International Consortium (COSMIC) is one of four international consortia led by UNSW Sydney’s Centre for Healthy Brain Ageing (CHeBA) to investigate risk and protective factors for dementia incidence and healthy brain ageing world-wide. COSMIC combines data from population-based longitudinal cohort studies to identify common risk factors for dementia and cognitive decline. Support for the consortia’s research is driven by CHeBA’s major philanthropic initiative, The Dementia Momentum. cheba.unsw.edu.au
About the Journal of Alzheimer’s Disease
Now in its 24th year of publication, the Journal of Alzheimer’s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment, and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. Groundbreaking research that has appeared in the journal includes novel therapeutic targets, mechanisms of disease, and clinical trial outcomes. JAD has a Journal Impact Factor of 4.472 according to Journal Citation Reports (Clarivate, 2021). The journal is published by IOS Press. j-alz.com