21 March 2018

The Journal of Alzheimer’s Disease (JAD) celebrates its 20th anniversary during 2018, with the publication of a special anniversary issue (JAD 62:3) in March. This is now available online, with all content open access and freely available to read for all, and features 35 review articles covering 20 years of Alzheimer’s disease (AD) research, plus personal perspectives from researchers in the field. Over the course of 20 years, JAD has published more papers on AD than any other journal and received more citations than any other AD-focused journal. Throughout the year we will celebrate the journal and, with the publication of this anniversary issue, it is time to take stock of the impact this publication has had – and continues to have – on research in the field and translating that research into clinical practice.
In the Foreword for this issue, JAD’s Editor-in-Chief George Perry, PhD recalls the early days of the journal: “The plan was to design a journal that reflected the field through creating community. Editorial structure, openness to novel topics, reviewer selection, scientometric analysis, awards programs, and historical compendiums were all focused on building a JAD community.” In this issue, it is the JAD community of authors that celebrates the past 20 years by writing of the journal’s role in developing the field. All content in this issue of JAD – co-edited by George Perry, PhD, Jesús Avila, MD, Massimo Tabaton, MD, and Xiongwei Zhu, PhD – has been specially commissioned. There are two personal perspectives: the first by Isidro Ferrer, MD, PhD is a broad-ranging, historical perspective covering Alzheimer’s to art and in it we are reminded that “the feeling of beauty may also occur in science”; and the second by Thomas B. Shea, PhD is a career-spanning perspective that includes “some of the more humorous and poignant twists along the way that some older players may find familiar and I hope might inspire some younger players to hang in there.” The remaining, bulk of the issue is made up of 35 review articles covering all aspects of AD research. The full contents is listed below; we invite you to browse through and click the links to be taken to the full articles. You can access the entire issue is also available via this link: http://tiny.cc/JAD-anniv
With the publication of this open access anniversary issue, the celebration of 20 years of JAD is now truly underway. In July 2018, there will be other special events happening and a commemorative publication will be launched. To be kept informed of our plans to commemorate JAD’s 20th anniversary, be sure to sign up to the JAD newsletter or contact us here.
JAD 20th Anniversary Issue (62:3) Contents
Foreword
- Birth of JAD: 20 Years Later – George Perry, Jesús Avila, Massimo Tabaton, Xiongwei Zhu
Perspectives
- Sisyphus in Neverland – Isidro Ferrer
- While I Still Remember: 30 Years of Alzheimer’s Disease Research – Thomas B. Shea
Review Articles
- Genetic Heterogeneity of Alzheimer’s Disease: Embracing Research Partnerships – Benedetta Nacmias, Silvia Bagnoli, Irene Piaceri, Sandro Sorbi
- Role of Genetics and Epigenetics in the Pathogenesis of Alzheimer’s Disease and Frontotemporal Dementia – Chiara Fenoglio, Elio Scarpini, Maria Serpente, Daniela Galimberti
- Aging without Dementia is Achievable: Current Evidence from Epidemiological Research – Chengxuan Qiu, Laura Fratiglioni
- Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model – Christian Griñán-Ferré, Rubén Corpas, Dolors Puigoriol-Illamola, Verónica Palomera-Ávalos, Coral Sanfeliu, Mercè Pallàs
- Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies – Ralph N. Martins, Victor Villemagne, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer B. Gupta, Stephanie R. Rainey-Smith, Eugene Hone, Steve Pedrini, Wei Ling Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O’Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J. Fuller, Belinda Brown, Samantha L. Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon M. Laws, Anna M. Barron, Kathryn Goozee, Eka J. Wahjoepramono, Prita R. Asih, James D. Doecke, Olivier Salvado, Ashley I. Bush, Christopher C. Rowe, Samuel E. Gandy, Colin L. Masters
- Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention – Francesco Panza, Madia Lozupone, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Francesca D’Urso, Roberta Stallone, Massimo Petruzzi, Gianluigi Giannelli, Nicola Quaranta, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Giancarlo Logroscino
- Immunotherapy of Mild Cognitive Impairment by ω-3 Supplementation: Why Are Amyloid-β Antibodies and ω-3 Not Working in Clinical Trials? – Milan Fiala, Lucas Restrepo, Matteo Pellegrini
- The Emergence of a New Conceptual Framework for Alzheimer’s Disease – Bruno Dubois
- The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades – José Luis Molinuevo, Carolina Minguillon, Lorena Rami, Juan Domingo Gispert
- Patient Engagement: The Fundació ACE Framework for Improving Recruitment and Retention in Alzheimer’s Disease Research – Mercè Boada, Miguel A. Santos-Santos, Octavio Rodríguez-Gómez, Montserrat Alegret, Pilar Cañabate, Asunción Lafuente, Carla Abdelnour, Mar Buendía, Maria José de Dios, América Morera, Ángela Sanabria, Laura Campo, Agustín Ruiz, Lluis Tárraga
- Amsterdam Dementia Cohort: Performing Research to Optimize Care – Wiesje M. van der Flier, Philip Scheltens
- Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin – Barbara Borroni, Alberto Benussi, Enrico Premi, Antonella Alberici, Elena Marcello, Fabrizio Gardoni, Monica Di Luca, Alessandro Padovani
- The Past and the Future of Alzheimer’s Disease Fluid Biomarkers – Kaj Blennow, Henrik Zetterberg
- Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy – Kurt A. Jellinger
- A Decade of Blood Biomarkers for Alzheimer’s Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication – Liu Shi, Alison L. Baird, Sarah Westwood, Abdul Hye, Richard Dobson, Madhav Thambisetty, Simon Lovestone
- Cerebrospinal Fluid Biomarkers for Early and Differential Alzheimer’s Disease Diagnosis – Maria Bjerke, Sebastiaan Engelborghs
- A Novel Therapeutic Approach to Treat Alzheimer’s Disease by Neurotrophic Support During the Period of Synaptic Compensation – Narjes Baazaoui and Khalid Iqbal
- Alzheimer’s Disease Can Be Spared by Nonsteroidal Anti-Inflammatory Drugs – Patrick L. McGeer, Jian Ping Guo, Moonhee Lee, Krista Kennedy, Edith G. McGeer
- Memantine for the Treatment of Dementia: A Review on its Current and Future Applications – Jaume Folch, Oriol Busquets, Miren Ettcheto, Elena Sánchez-López, Ruben Dario Castro-Torres, Ester Verdaguer, Maria Luisa Garcia, Jordi Olloquequi, Gemma Casadesús, Carlos Beas-Zarate, Carme Pelegri, Jordi Vilaplana, Carme Auladell, Antoni Camins
- The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer’s Disease – Elena Tamagno, Michela Guglielmotto, Debora Monteleone, Giusi Manassero, Valeria Vasciaveo, Massimo Tabaton
- Translational Research in Alzheimer’s and Prion Diseases – Giuseppe Di Fede, Giorgio Giaccone, Mario Salmona, Fabrizio Tagliavini
- Alzheimer’s Disease, Oligomers, and Inflammation – Gianluigi Forloni, Claudia Balducci
- Our Working Point of View of Tau Protein – Jesús Avila
- Modeling Prion-Like Processing of Tau Protein in Alzheimer’s Disease for Pharmaceutical Development – Claude M. Wischik, Björn O. Schelter, Damon J. Wischik, John M. D. Storey, Charles R. Harrington
- Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms – Ying Yang, Jian-Zhi Wang
- A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks – Patrizia Mecocci, Virginia Boccardi, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Carmelinda Ruggiero, Marta Baroni
- Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology – Antonio Di Meco, Jian-Guo Li, Domenico Praticò
- Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease – D. Allan Butterfield, Debra Boyd-Kimball
- Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic? – Paul A. Adlard, Ashley I. Bush
- The 20-Year Voyage Aboard the Journal of Alzheimer’s Disease: Docking at ‘Type 3 Diabetes’, Environmental/Exposure Factors, Pathogenic Mechanisms, and Potential Treatments – Suzanne M. de la Monte, Ming Tong, Jack R. Wands
- Sweet Mitochondria: A Shortcut to Alzheimer’s Disease – Paula I. Moreira
- Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease – Russell H. Swerdlow
- Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease – Anders Wallin, Gustavo C. Román, Margaret Esiri, Petronella Kettunen, Johan Svensson, George P. Paraskevas, Elisabeth Kapaki
- The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment? – Patrick Gavin Kehoe
- Progress and Challenges in Frontotemporal Dementia Research: A 20-Year Review – John R. Hodges, Olivier Piguet