New Neuroimaging Analysis Technique Identifies Impact of Alzheimer’s Disease Gene in Healthy Brains

16 November 2009

Amsterdam – Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer’s Disease.

Investigators used automated neuroimaging analysis techniques to characterize the impact of an AD-risk gene, apolipoprotein E (ApoE4), on gray and white matter in the brains of cognitively healthy elderly from the KU Brain Aging Project.

They found that healthy elderly individuals carrying a risk-allele of the ApoE4 gene had reduced cognitive performance, decreased brain volume in the hippocampus and amygdala (regions important for memory processing), and decreased white matter integrity in limbic regions. These type of brain changes are also found in people with AD. Therefore, brain changes, usually found in AD patients, are also evident in nondemented individuals who have a genetic risk of later developing AD.

Lead investigator, Robyn Honea, DPhil, Research Assistant Professor, University of Kansas School of Medicine, Department of Neurology, Alzheimer's and Memory Group, comments, “It is important to note that findings of imaging phenotypes of risk variants, such as with this gene, have been shown in a number of studies. The unique element of our study is that we used several new neuroimaging analysis techniques. In addition, the individuals in our study have been well-characterized in a clinical setting.”

This research was conducted in the laboratory of Jeffrey M. Burns, MD, Associate Professor in the Department of Neurology at the University of Kansas Medical Center. He is the Director of the Alzheimer and Memory Center and the Alzheimer’s Disease Clinical Research Program. Dr. Burns serves as the Principal Investigator of the Brain Aging Program.

Reference: Honea, Robyn A., Eric Vidoni, Amith Harsha and Jeffrey M. Burns.  Impact of APOE on the Healthy Aging Brain: A Voxel-Based MRI and DTI Study. J Alzheimers Dis 18:3 (November 2009).

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To receive a copy of the full text, please contact Saskia van Wijngaarden at IOS Press, Tel: +31 20 688 3355, s.van.wijngaarden@iospress.nl. To request an interview with Professor Robyn A. Honea please contact Dennis Minich, Senior Coordinator Media Relations, KU Medical Center, +1 913 588-5246, DMINICH@kumc.edu.

Contacts:
George Perry, PhD
Editor-in-Chief, Journal of Alzheimer's Disease
University of Texas at San Antonio, College of Sciences
Tel: +1 210 458 4450
Fax:+1 210 458 4445
E-mail: george.perry@utsa.edu

Mark A. Smith, PhD
Editor-in-Chief, Journal of Alzheimer's Disease
Department of Pathology, Case Western Reserve University
Tel: +1 216 368 3670
Fax: +1 216 368 8964
E-mail: mark.smith@case.edu

Saskia van Wijngaarden
IOS Press
Tel: +31 20 688 3355
Fax: +31 20 620 3419
E-mail:s.van.wijngaarden@iospress.nl
URL: www.j-alz.com