A New Study Indicates Measuring the Progression of Alzheimer’s Disease by Monitoring Major Brain Antioxidant Levels Using Non-Invasive Techniques

12 October 2018

Dr. Pravat Mandal

Gurgaon, India In a breakthrough human study published in the Journal of Alzheimer's Disease, anti-oxidant glutathione (GSH), which protects the brain from stress, has been found to be significantly depleted in Alzheimer's patients compared to normal subjects.

As GSH is a very important anti-oxidant that protects the brain from free radicals, the findings give us another measure to use when diagnosing potential for the advancement of Alzheimer’s disease (AD) or recognizing those that are in the throes of Alzheimer’s advancement.

By implementing non-invasive imaging techniques, Dr. Pravat Mandal (pictured) and his team of researchers found that GSH has two conformations (closed and extended forms) in the brain. It was discovered that when GSH is depleted in the hippocampus regions of an elderly person the healthy brain suffers mild cognitive impairment (MCI), which is known to be present in the earlier stages of AD.

It is now correlated that closed form of GSH is depleted in AD patients. At present no report is available to indicate to what extent the lower levels of extended form of GSH in those suffering from AD can be measured but it opens the possibility for further clinical observation using GSH as supplement to combat the advancement of AD.

“If routine non-invasive tests for lower levels of GSH in the hippocampus regions are performed, we might be able to mitigate the advancement of Alzheimer’s disease by providing GSH supplements  an observational study is planned,” Dr. Mandal said.

The multi-continent research team lead by Dr. Mandal, led this breakthrough research and this research has a huge potential for therapeutic development for AD.

This research was funded by Tata innovation Fellowship (to Dr. Mandal).


Full open access study: Shukla D, Mandal PK, Ersland L, Renate Grüner E, Tripathi M, Raghunathan P, Sharma A, Chaithya GR, Punjabi K, Splaine C. A Multi-Center Human Brain Glutathione Conformation Study from Magnetic Resonance Spectroscopy. J Alzheimers Dis. 2018 Sep 1. doi: 10.3233/JAD-180648. [Epub ahead of print]

Dr. Pravat K. Mandal
Professor, Neuroimaging and Neurospectroscopy Laboratory
National Brain Research Centre, Gurgaon, India
Emails: pravat.mandal@gmail.com; pravat@nbrc.ac.in
Honorary Professorial Fellow
Florey Institute of Neurosciences and Mental Health
University of Melbourne Medical School Campus
Melbourne, Victoria, Australia
Email: pravat.mandal@florey.edu.au

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Diana Murray
IOS Press
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About the Journal of Alzheimer's Disease
Celebrating its 20th anniversary in 2018, the Journal of Alzheimer's Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. Groundbreaking research that has appeared in the journal includes novel therapeutic targets, mechanisms of disease and clinical trial outcomes. JAD has an Impact Factor of 3.476 according to the 2017 Journal Citation Reports (Clarivate Analytics, 2018). j-alz.com