Manuscript Number: 16-1172R1 Author(s): Keigo Dote, Tasuku Higashihara, Eisuke Kagawa, Masaya Kato, Shunsuke Miyauchi, Michiaki Nagai, Yoshinori Nakano, Noboru Oda, Shota Sasaki, Akane Tsuchiya, Aya Yamane