Manuscript Number: 21-0517R1 Author(s): Lin Cong, Yifeng Du, Xiaodong Han, Xiaolei Han, Tingting Hou, Ziying Jiang, Miia Kivipelto, Lenore J. Launer, Tiia Ngandu, Chengxuan Qiu, Shi Tang, Yongxiang Wang, Bengt Winblad