Manuscript Number: 21-5061R1 Author(s): Natalia Altomari, Amalia C. Bruni, Francesco Bruno, Rosanna Colao, Sabrina Curcio, Raffaele Di Lorenzo, Francesca Frangipane, Valentina Laganà, Raffaele Maletta, Gianfranco Puccio, Nicoletta Smirne