Longitudinal associations of plasma TMAO and related metabolites with cognitive impairment and dementia in older adults: the Cardiovascular Health Study

Manuscript Number: 

22-0477R2

Author(s): 
Amanda Fretts, Stanley L. Hazen, Heidi Tsz Mung Lai, Yujin Lee, Rozenn N. Lemaitre, Xinmin S. Li, Oscar Lopez, Dariush Mozaffarian, Ina Nemet, Anne B. Newman, David Siscovick , W.H. Wilson Tang, Meng Wang, Zeneng Wang, Marcia C. de Oliveira Otto

Disclosures

Marcia C. de Oliveira Otto

  • Nothing to Disclose

Amanda Fretts

  • Nothing to Disclose

Stanley L. Hazen

  • Consulting Fees:
    Dr. Hazen is a paid consultant formerly for Procter & Gamble and currently with Zehna Therapeutics.
    Patents/Royalties
    Dr. Hazen reports being named as co-inventor on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. He is eligible to receive royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland HeartLab, a wholly owned subsidiary of Quest Diagnostics, Procter & Gamble and Zehna therapeutics.
    Grants
    • Agency: 
      Proctor and Gamble
    • Agency: 
      Zehna Therapeutics
    • Agency: 
      Roche Diagnostics

Heidi Tsz Mung Lai

  • Nothing to Disclose

Yujin Lee

  • Nothing to Disclose

Rozenn N. Lemaitre

  • Nothing to Disclose

Xinmin S. Li

  • Nothing to Disclose

Oscar Lopez

  • Consulting Fees:
    Consultant for: Eisai, Biogen, Novo Nordic, Grifols

Dariush Mozaffarian

  • Nothing to Disclose
    Consulting Fees:
    Dr. Mozaffarian reports research funding from the National Institutes of Health, the Gates Foundation, The Rockefeller Foundation, Vail InnovativeGlobal Research, and Kaiser Permanente;personal feesfrom Acasti Pharma, Barilla, Danone, and MotifFoodWorks;scientific advisory board, Beren Therapeutics, Brightseed, Calibrate, Discern Dx, Elysium Health, Filtricine, HumanCo, JanuaryInc., Perfect Day,Tiny Organics, and (ended) Day Two and SeasonHealth; stock ownership in Calibrate and HumanCo; and chapterroyalties from UpToDate.

Ina Nemet

  • Nothing to Disclose

Anne B. Newman

  • Nothing to Disclose

David Siscovick

  • Nothing to Disclose

W.H. Wilson Tang

  • Consulting Fees:
    Sequana Medical A.V. - consulting fees Cardiol Therapeutics Inc - consulting fees Genomics plc - consulting fees Zehna Therapeutics LLC - consulting fees Renovacor Inc - consulting fees American Board of Internal Medicine - exam writing committee Springer Nature - editor and author

Zeneng Wang

  • Patents/Royalties
    patents: Trimethylamine-containing compounds for diagnosis and prediction of disease; royalty; from Procter & Gamble, Cleveland Heart Lab

Meng Wang

  • Nothing to Disclose