Manuscript Number: 11-0140R2 Author(s): Eri Himeno, Kyoko M. Iinuma, Jun-ichi Kira, Linqing Ma, Katsue Miyoshi, Norimichi Nakamura, Yasumasa Ohyagi, Nobutaka Sakae, Naoko Soejima, Ryo Yamasaki, Yuki T. Yanagihara