Cerebrospinal Fluid Biomarkers Distinguish Postmortem Confirmed Alzheimer's Disease from Other Dementias and Healthy Controls in the OPTIMA Cohort

Manuscript Number: 

14-1725R1

Author(s): 
Derek Chappell, Marc Combrinck, Aimee Dallob, Mary Flynn, Daniel J. Holder, Catharine Joachim, Omar F. Laterza, Vijay Modur, William Potter, Mary J. Savage, Jeffrey L. Seeburger, Adam Simon, A. David Smith, Karen Snyder, Michael Tanen, Gordon Wilcock

Disclosures

Derek Chappell

  • Equity:
    I own Merck stock options.
    Sponsors:
    Merck employee

Marc Combrinck

  • Nothing to Disclose

Aimee Dallob

  • Nothing to Disclose

Mary Flynn

  • Nothing to Disclose

Daniel J. Holder

  • Equity:
    Own stock in Merck
    Sponsors:
    Employed by Merck&Co Inc.

Catharine Joachim

  • Nothing to Disclose

Omar F. Laterza

  • Equity:
    stock and stock options, Merck & Co., Inc.
    Sponsors:
    Employee of Merck & co., Inc.
    Patents/Royalties
    Patents and patents applications

Vijay Modur

  • Equity:
    HTG Molecular Diagnostics, Inc
    Sponsors:
    During the performance of the study, I was employed by Merck & Co., Inc.
    Patents/Royalties
    I am an inventor on patent on AD diagnosis for the protein VSNL1 and may potentially receive royalties.

William Potter

  • Consulting Fees:
    Amgen AgeneBio Lilly Theravance Taisho Ironside Neurotrope
    Equity:
    Merck

Mary J. Savage

  • Equity:
    I own stock and stock options in Merck and Company, my employer
    Sponsors:
    I am an employee of Merck and Company, who funded a portion of the work.
    Patents/Royalties
    I have one patent with Merck and company in the area of amyloid vaccine.

Jeffrey L. Seeburger

  • Nothing to Disclose

A. David Smith

  • Nothing to Disclose

Karen Snyder

  • Nothing to Disclose

Michael Tanen

  • Nothing to Disclose

Gordon Wilcock

  • Consulting Fees:
    I have been a member of several advisory boards to industry, but none is in conflict with this paper. However I will list the companies: Roche Cytox GSK

Adam Simon

  • Disclosure not yet completed