Manuscript Number: 17-0749R2 Author(s): Kiyoshi Fukushi, Makoto Higuchi, Shigeki Hirano, Toshiaki Irie, Satoshi Kuwabara, Tsuneyoshi Ota, Koichi Sato, Hitoshi Shimada, Hitoshi Shinotoh, Tetsuya Suhara, Noriko Tanaka, Ming-Rong Zhang