Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model.

Sil A, Erfani A, Lamb N, Copland R, Riedel G, Platt B
J Alzheimers Dis. 2022; 85(2):755-778. PMID: 34864660. Abstract

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Annesha et. found that female 5XFAD mice had higher amounts of human APP and Aβ and heightened inflammation compared to males. Only female 5XFAD mice showed subtle deficits in object and social exploration, while male animals expressed more stress markers and neurotrophic factors. Male and female mice have different molecular profiles, which provides insight into putative protective mechanisms and therapeutic techniques.

Annesha et. found that female 5XFAD mice had higher amounts of human APP and Aβ and heightened inflammation compared to males. Only female 5XFAD mice showed subtle deficits in object and social exploration, while male animals expressed more stress markers and neurotrophic factors. Male and female mice have different molecular profiles, which provides insight into putative protective mechanisms and therapeutic techniques.