Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia.

Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O
Arch Gen Psychiatry. 2012 Jan; 69(1):98-106. PMID: 22213792. Abstract
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