The past 10-20 years have seen an exponential growth in the scientific literature on dementia, the identification of dementia risk factors, and the potential for risk reduction. We now benefit accordingly from a broad consensus as to the main modifiable and lifestyle factors that have been associated with an increased risk of developing dementia or cognitive decline (for a review, see Anstey et al. ).
However, despite our knowledge of the potential risk factors, the evidence for successful risk reduction has been slower to accrue. Given the evidence that multiple risk factors influence cognitive trajectories, the field has moved towards multifactorial interventions where several risk factors are tackled at once. Clinical trials using this approach are growing in popularity and prevalence [2-5] with protocols for two such trials reported in this supplemental issue [2,3]. Building on this, and in order to optimise the efficacy of risk reduction, we now need to drill down to the best evidence and to understand how this applies in different populations. The IRNDP supplemental issue [1-4,5-19] highlights how there remains an urgent need to build a more targeted risk reduction strategy. The issue includes new evidence on varied populations including aboriginal Australians, community dwelling Japanese elders, Malaysian, Portuguese, Brazilian, and Mozambican adults [7,8,17,18]. It reports on emerging risk factors such as air pollution, kidney disease, and chronic obstructive pulmonary disease [10-12] and on new analyses on the impact of modifiable and non-modifiable risk factors and changes in incidence over time [13-16]. In thoughtful editorials, Glymour and Whitmer  and Brayne and Richard  draw these findings together orientating us to both the potential but also to the gaps in the current epidemiology and trials-based approaches. Sexton and Yaffe  take this further highlighting the need for cultural awareness and the potential for locally-based risk reduction initiatives [18,19]. Overall the message from the research is that we need not only to continue to critically appraise and synthesize what we already know but also to develop new research to gather the more detailed information we currently lack.
Two key current unknowns for most if not all of the dementia risk factors include:
gaps in the data on optimal risk factor exposure for the best protection of brain and cognitive health  and
a lack of knowledge relating to the relative impact and relevance of the varied risk factors in different population groups . Such population groups of course include sex and ethnicity but geographical, cultural, and genetic factors must also be considered, particularly if or rather when we design risk reduction messages targeted to such groups.
This supplemental issue of the Journal of Alzheimer’s Disease is sponsored by the International Research Network on Dementia Prevention (IRNDP) (see www.IRNDP.com) with a view to prompting thought and supporting discussion and scientific endeavour in this area.
The supplemental issue brings together a unique collection of dementia prevention related research that serves to highlight and starts to fill the gaps in our current knowledge of the area. This will help build the evidence base but we must not forget the importance of evaluating and testing the means and messages we use to communicate our dementia risk reduction information. This should be considered in parallel as we develop the literature to support the messaging, ensuring that we use appropriate and successful means to identify and reach those who need to hear them [7,9,18,19].
The dementia risk reduction field has come a long way in recent years but we have only painted in the broad-brush strokes so far. We know that living a healthy lifestyle, eating a healthy diet, physical activity, maintaining a healthy weight, taking appropriate clinical treatment to manage conditions such as hypertension, and staying socially and cognitively active are unlikely to harm and may protect brain health. We now need the information to be able to apply and tailor these messages to a global population to achieve the most robust and sustained benefit we can. This issue showcases some of the work that is taking us towards this goal.