Letters to the Editor

6 May 2014

Response to: Kapila et al. (2014) J Alzheimers Dis, doi: 10.3233/JAD-132258

It was with great interest that we encountered the recent article by Kapila et al. [1]. The preclinical studies from this group have contributed significantly to our understanding of the relationship between the perioperative period and cognitive loss. However, with respect to translation, we believe that a much more cautionary note is due here than presented by the article. First, the evidence in humans that the perioperative period is linked to incident dementia is weak at best. Many contradictory clinical studies exist and there is simply no consensus at this point.

16 April 2014

Updated meta-analysis of SORL1 in Alzheimer's disease: Unmet concerns

I have read with interest the recent report by Jin and coworkers on the putative role of SORL1 variants in sporadic Alzheimer’s disease [1]. In their report, the authors claim a significant effect of a three-marker haplotype, but refute a second haplotype based on twenty-three case-control studies. This conclusion, it seems, is premature in view of glaring oversights.

14 April 2014

How Progressive Supranuclear Palsy (PSP) is Mimicked and What is Mimicking PSP?

PSP-like Features without PSP Cytopathology in Three Cases of Alzheimer’s Disease/Parkinson’s DiseaseProgressive supranuclear palsy (PSP) is a progressive disabling neurodegenerative disorder manifested clinically by vertical supranucelar gaze palsy or slowing of vertical saccades, prominent postural instability, and falls. Its neuropathological substrate is 4 repeat tau deposition as neurofibrillary tangles in the basal ganglia and brainstem and tuft-shaped astrocytes.

2 February 2014

Response to: Avidan and Evers (2011) J Alzheimers Dis 24, 201-216

The topic of long term cognitive impairment is of concern to patients and clinicians and it is critical that it be addressed with appropriately designed studies. It is disappointing to note that despite a plethora of opinion pieces dominating the literature, there remain no prospective studies investigating dementia following surgery and anesthesia.

8 October 2013

Postmortem changes in brain levels of GGA1 and GGA3 in mice

We read with interest the article by Natunen et al. [1] on the role of the BACE regulating factor, GGA3, in Alzheimer’s disease (AD). In this study, as has been the case with a number of other studies [2-4], the authors utilized human postmortem brain samples to show that the temporal cortex of AD patients had decreased levels of GGA3 compared to that of age-matched controls, although the decrease was not statistically significant [1]. In a separate study, Santosa et al.

1 September 2013

On a solution to the riddle of “amyloid made” versus “amyloid regulated” channels in cell membranes

The paper recently presented by Lee et al. [1] impressively broadens the debate on the effects of soluble amyloid-β (Aβ) peptide oligomers applied at the cell surface of neurons and thus again fuels the question formulated in the headline. The authors, examining the impact of exogenously applied Aβ on signaling in neurons cultured on multi-electrode arrays, observed that subcytotoxic amounts of human Aβ1-42 perturbed synaptic transmissions within hours.

27 May 2013

Optical coherence tomography (OCT) use in non-Alzheimer’s disease (AD) dementias

We read with great interest the article by Moreno and colleagues [1]. The authors should be congratulated on enlarging our knowledge on retinal nerve fiber layer (RNFL) thickness measurements in Alzheimer’s disease (AD) and other types of dementia. The results of this study show that optical coherence tomography (OCT) seems to be a useful tool for diagnosing dementia syndromes but does not seem to contribute to the differential diagnosis of different types of dementia. Nevertheless, we believe that some supplementary discussion of the problem is needed.

1 March 2013

Response to: Rembach A et al. (2013) J Alzheimers Dis 34, 171-182

We have read with great interest the study by Rembach and colleagues [1] on the diagnostic value of serum copper (Cu), ceruloplasmin (CP), and ‘free’ Cu also named non-CP Cu, in the Australian Imaging Biomarkers and Lifestyle Study of Aging (AIBL). When discussing their results, these authors commented that some studies of ours on the relationship between serum non-CP Cu and Alzheimer’s disease (AD) [2-8] were produced in cohorts not adjusted for age and gender.

1 December 2012

Response to: Hebda-Bauer EK et al. (2013) J Alzheimers Dis 33, 407-422

Recently, numerous lifestyle factors have been described that influence the risk of dementia such as smoking, obesity, and physical exercise, or certain nutrients like selenium [1]. Another factor that has received little attention to so far, although it might be of crucial importance in the modern human environment with its increasing complexity and speed-up of daily events, is stress. Psychological stress occurs when individuals face situational demands that exceed their adaptive capacity.

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