1 December 2010
The article by Walton  indicated aluminum is instrumental in causing hyperphosphorylation of tau with subsequent development of neurofibrillary tangle formation. Recently tau has been found to mislocalize to dendritic spines causing early synaptic dysfunction . Aluminum mediated hyperphosphorylation of tau may be a trigger for tau dysfunction and abnormal cellular trafficking with mislocalization to dendrites causing synaptic dysfunction, which probably is an early feature of Alzheimer's disease.
1 May 2010
We thank Dr. Kumlin and colleagues for their insightful comments regarding our paper . Inasmuch as we were unaware of their earlier study involving EMF exposure to normal rats , we did not include it among the references in our paper and apologize for this oversight. Kumlin et al.  did indeed provide initial evidence that long-term EMF exposure (2 hrs/day, 5 days/week, for 5 weeks) can improve cognitive performance in rodents. It is important to note, however, that they provided EMF exposure to very young rats from 3-8 weeks of age.
1 May 2010
We note that Perucho et al.  cite (reference number 28) a 2007 publication by Pravat K Mandal , and we wish to point out to the authors and your readers that the Biochemistry paper in question was retracted later that same year , as was another article by Mandal , because “the anesthetic concentration of our paper[s] was misrepresented”. Those papers should therefore not be cited as evidence.
1 April 2010
In a recent issue of Journal of Alzheimer’s Disease, Zhang and colleagues presented interesting data concerning the cholinergic deficit in Alzheimer’s disease (AD) . These results demonstrated decreases in the activity of acetylcholinesterase (AChE) and reduced mRNA levels of α4 and β2 nicotinic acetylcholine receptor (nAChR) subunits in peripheral blood of patients with AD in an elderly Chinese population.
1 March 2010
To the Editors, Like many with an interest in the field of Alzheimer’s disease I was intrigued to read the recent paper in JAD which purported to report the ‘scientific productivity and impact of the top 100 investigators in the field’ . As an outsider to the study of ‘scientometrics’ it appeared a thorough piece of work though there were few indications as to its actual aims.
1 March 2010
A very interesting article by Arendash et al. (1) was published in the January 2010 issue of Journal of Alzheimer’s Disease. The results suggested that exposure to radiofrequency (RF) radiation similar to that emitted by mobile phones may provide cognitive benefits both in normal mice and in a transgenic mouse model of Alzheimer’s disease (AD).