Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy.
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Pathology, Methods
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Neuroinflammation in AD
Neuroinflammation occurred in the whole course of AD, and antiinflammatory cytokines including IL-4 and IL-10 stimulate microglia ,which may be a therapeutic potential way.
paper by McGeer EG & McGeer PL, J Alzh Dis 19(1)355-61, 2010
The fact that aggregated amyloid-beta is not a potent activator of mouse complement system is often forgotten when studying AD-related neuroinflammation by using mouse models. This is an important difference to be kept in mind when extrapolating the murine data to human pathology.
This paper shows the
This paper shows the importance to consider the inflammatory nature of brain damage in AD.
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