Propagation of tau pathology in a model of early Alzheimer's disease.
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Their data suggest that a
Their data suggest that a sequence of progressive misfolding of tau proteins, circuit-based transfer to new cell populations, and deafferentation induced degeneration are part of a process of tau-induced neurodegeneration.
evolution rules of neurofibrillary tangles
The authors expounds the evolution rules of neurofibrillary tangles with disease progression in transgenic mouse model, which provides an important reference information of changes of nerve fibers detected by diffusion tensor imaging.
interesting model
Tha authors developped an interesting animal model that allowed them to unravell the sequence of events from expression of pathological tau in the entorhinal cortex to the development of widespread cortical involvement. They identified the specific sequence of progressive misfolding of tau proteins that, transfering to new cell populations, induced degeneration.
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