YuHong Fu, PhD

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
January 31, 2016
The study shows that the hippocampal formation and, to a lesser degree, the cerebellar cortex in AD cases without diabetes...
Caspase signalling controls microglia activation and neurotoxicity.
January 31, 2016
The study shows that caspase-8 and caspase-3/7 are involved in regulating microglia activation, therefore, inhibition of these...
Predicting regional neurodegeneration from the healthy brain functional connectome.
January 31, 2016
The findings best fit a transneuronal spread model of network-based vulnerability.
Propagation of tau pathology in a model of early Alzheimer's disease.
January 31, 2016
Their data suggest that a sequence of progressive misfolding of tau proteins, circuit-based transfer to new cell...
REST and stress resistance in ageing and Alzheimer's disease.
January 30, 2016
The study suggestes that the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing...
Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
January 30, 2016
The study suggests a mechanism to account for the vulnerability of specific brain regions to Aβ deposition in Alzheimer's...
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways.
January 30, 2016
This work identifies convergent and divergent pathways in mouse and human, and provides a systematic framework that will be...