Cognitive reserve in ageing and Alzheimer's disease.

Stern Y
Lancet Neurol. 2012 Nov; 11(11):1006-12. PMID: 23079557. Abstract
Top50 Topics: 
Physiology

Comments

This article information is interesting because to assess cognitive reserve holds out the promise of interventions that could slow cognitive aging or reduce the risk of dementia.

This paper provides a detailed and incisive overview of one of the most interesting hypothesis formulated in the field, i.e. cognitive reserve as explanation for inter-individual differences in functional changes due to AD and as potential target to slow down cognitive aging or reduce risk of dementia.

Submitted by Wei Chen on

Greater understanding of cognitive reserve and brain reserve is important for intervention of AD.

This article is of great interest as underline how brain can differently react to a pathological process also thank to modifiable factors.

This paper is a seminal work for the definition of both cognitive reserve and brain reserve and to understanding their role in the natural history of Alzheimer's disease.

The review provides a comprehensive overview of the "state of the art" about the cognitive reserve. Most importantly, it provides a discussion about the brain reserve and suggests that fMRI pattern may represent its functional and measurable correlate.

This article information is interesting because this review provides provides a discussion about the brain reserve and suggests.