Akihiko Nunomura, M.D., Ph.D.

JAD profile

Regional Editor

Term Expiration: 

12/31/2027

Affiliation(s): 

Department of Psychiatry; Jikei University School of Medicine

Lab URL: 

http://www.jikei.ac.jp/eng/index.html

Areas of Interest: 

Brain Aging and Dementia, Oxidative Stress and Neurodegeneration, RNA Biology and Neuropsychiatry

Biography & Research: 

Nunomura A, Perry G. RNA and oxidative stress in Alzheimer’s disease: Focus on microRNAs. Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 2638130, 16 pages, 2020. https://doi.org/10.1155/2020/2638130 Nunomura A, Lee HG, Zhu X, Perry G. Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders. Biochemical Society Transactions 45(5):1053-1066, 2017 Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicity Research 22(3):231-248, 2012 Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW Jr, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. Journal of Neuropathology & Experimental Neurology 71(3):233-241, 2012 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease 37(3):731-737, 2010 Nunomura A, Hofer T, Moreira PI, Castellani RJ, Smith MA, Perry G. RNA oxidation in Alzheimer disease and related neurodegenerative disorders. Acta Neuropathologica 118(1):151-166, 2009 Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer　disease. Journal of Neuropathology & Experimental Neurology 65(7):631-641, 2006 Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of familial Alzheimer’s disease. Neurobiology of Disease 17(1):108-113, 2004 Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology & Experimental Neurology 60(8):759-767, 2001 Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome. Journal of Neuropathology & Experimental Neurology 59(11):1011-1017, 2000 Perry G, Nunomura A, Raina AK, Smith MA. Amyloid β junkies. Lancet 355(9205):757, 2000 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer’s disease. Journal of Neuroscience 19(6):1959-1964, 1999 Nunomura A, Perry G, Hirai K, Aliev G, Takeda A, Chiba S, Smith MA. Neuronal RNA oxidation in Alzheimer’s disease and Down’s syndrome. Annals of the New York Academy of Sciences 893:362-364, 1999 Perry G, Nunomura A, Lucassen P, Lassmann H, Smith MA. Apoptosis and Alzheimer’s disease. (letter) Science 282(5392):1268-1269, 1998 Perry G, Nunomura A, Smith MA. A suicide note from Alzheimer disease neurons? (News & Views) Nature Medicine 4(8):897-898, 1998