Patrick Dutar, PhD
Primary tabs
JAD profile
Affiliation(s):
INSERM U894; Center of Psychiatry and Neuroscience
Areas of Interest:
ageing, synaptic plasticity, Alzheimer's models, electrophysiology
Biography & Research:
Using electrophysiological approaches, we study the regulation of NMDA receptors by its co-factor D-serine and its enzymes. To precise age-related changes in D-serine synaptic turnover, to determine the role of D-serine in pathological aging, to assess D-serine-dependent strategies for reducing cognitive aging and to determine the role of D-serine in neurotoxicity linked to Alzheimer’s disease.
Research on AD models. The future of AD research is based on the early events occurring at the beginning of the disease. Only the knowledge of the earliest mechanisms responsible of the shift from a normal destiny to a pathological one will lead to decisive progress in the therapies. We perform plasticity and patch-clamp studies in rats and mice modelling the early stages of AD.
