Hervé Tricoire, PhD
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Affiliation(s):
Unité de Biologie Fonctionnelle et Adaptative
Areas of Interest:
aging, neurodegeneration, polyQ diseases, ataxias, Huntington's disease, Alzheimer disease, mitochondria
Biography & Research:
After an initial carrier in CNRS as a nuclear physicist, HT has been working for 15 years on mechanisms of normal and pathological aging with an emphasis on polyQ diseases and on the role of oxidative stress in these processes. From 2009 HT leads the team "Degenerative processes and aging" in the BFA unit. These last years, our team has been involved in the generation and characterization of inducible Drosophila model of polyQ diseases (HD, SCA1, SCA3 and SCA7), the identification of genetic modifiers and drug library screening, inside the EUROSCA and ITN TreatPolyQ networks. HT also coordinated in the period 2008-2012 a French ANR consortium (NEUROMIR) that aimed to assay a potential role of miRNA in different Drosophila models of neurodegeneration (tauopathies, Parkinson and SCA1, 2, 3 and 7 diseases). In addition to this work on polyQ disease, since 2011, HT conducts studies on Alzheimer's disease and Friedreich ataxia (FA), a complex recessive ataxia with neuronal and cardiac impairment. An in vivo library drug screening, funded by the FA Research Association, is currently in progress in the lab.
Our team has also important involvement in identifying pathways involved in Drosophila aging either at the level of the whole organism or in non replicative organs like heart or neurons. Both genetic and genomic approaches have been used for this purpose. A special emphasis has been put these last years on the role of mitochondria with potential connections to degenerative models. The current interest of our team is on the characterization, by genetic, genomic and proteomics approaches, of new aging genes, including those involved in specific phases of lifespan identified recently by Michael Rera and modelized in a discontinuous model of aging.
