Simon Laws, BSc Hons PhD
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JAD profile
Affiliation(s):
Edith Cowan University
ORCID URL:
Areas of Interest:
Alzheimer's disease, genetics, epigenetic, cognitive decline, amyloid and tau pathology/accumulation, age at onset
Biography & Research:
I currently lead The Collaborative Genomics Group, within the Centre for Precision Health, which is an Edith Cowan University Strategic Research Centre. My research primarily focuses on understanding the genetic and epigenetic architecture of Alzheimer’s Disease and related phenotypes, such as changes in memory performance and pathognomonic features. My group utilizes an integrative “omic” approach to Alzheimer’s Disease research through combining genetic, epigenetic and comprehensive longitudinal phenotype data.
My current research focuses on:
1. Understanding the Genomic Architecture of Rates of Change in AD-related Phenotypes
- Develop genetic/epigenetic risk profiles for rates of change
- Determine if peripheral methylation patterns track with AD phenotypes
2. Assessing the interaction of genomics and modifiable lifestyle factors and the impact on rates of change in AD-related phenotypes
- Understanding the genetic basis of differential effects of lifestyle patterns/choices
- Determine the impact of positive lifestyle choices on peripheral methylation patterns
