Paul Hopkins, Ph.D.
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Affiliation(s):
King's College London
Areas of Interest:
Alzheimer disease, ApoE, cardiovascular disease, inflammation
Biography & Research:
My work focuses on apolipoprotein E (apoE), a protein important in diseases from Alzheimer’s disease, blunt head trauma and stroke, macular degeneration, cardiovascular disease, as well as rare forms of inherited kidney disease and both HIV and herpes simplex infectivity.
At the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, I identified TMCC2, a previously unstudied protein, as a potential mediator of the effect of apoE in Alzheimer’s disease. I showed that TMCC2 interacted differentially with risk versus normal versions both apoE and the amyloid precursor protein, another protein central to the aetiology of Alzheimer’s disease. A role for TMCC2 in neurodegeneration was also suggested when an allele of Drosophila TMCC2 (Dementin) caused Alzheimer’s disease-like pathology and early death.
My previous experience was in mouse models of apoE function, gained at the Gladstone Institutes, UC San Francisco, through investigating isoform-specific effects of apoE on lipoprotein metabolism and atherosclerotic lesion development and Alzheimer’s disease.
