Dongming Cai, MD, M.D. Ph.D.
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Affiliation(s):
Icahn School of Medicine at Mount Sinai; James J Peters VA Medical Center
Areas of Interest:
cell and molecular biology of neurodegenerative diseases, Biomarkers for Alzheimer's disease, Alzheimer's Disease therapy
Biography & Research:
I have a broad background in neuroscience, with specific expertise in key research areas for neurodegenerative diseases. Since I joined ISMMS as an independent investigator, my research program has been focused on studying the regulation of phospholipid composition and metabolism in Alzheimer’s disease pathogenesis. We have characterized functional roles of phospholipid regulators: dynamin and synaptojanin 1, in regulating AD-related protein trafficking, Aβ metabolism and degradation using AD transgenic animal models with genetic perturbation of these regulators. We have been studying the regulation of phospholipid homeostasis by ApoE isoforms and their functional roles in AD pathogenesis. Our studies are the first mechanistic studies that link ApoE4 genotype-specific changes in phospholipid homeostasis of neurons to ApoE4-increased susceptibility to develop AD. These studies may uncover new therapeutic options for the treatment of sporadic AD.
