Juan Marín Muñoz, MD - Neurologist

JAD profile

Affiliation(s): 

Instituto Murciano de Investigación Biosanitaria

Areas of Interest: 

Alzheimer Disease and other Dementias

Biography & Research: 

General practitioner at the University of Cadiz-1985-1991 Neurologist at the Hospital Reina Sofía de Córdoba 1994-1997. Researcher sufficiency at the University of Córdoba in the human histomorphometry program between 1995 and 1996 General Practitioner and Neurologist of the Spanish Armed Forces between 1998 and 2004 Neurologist at Hospital Rafael Méndez de Lorca, Murcia, Spain between 2004 and 2006 Degree in Neuropsychology and Dementias by the University of Barcelona between 2006 and 2007 Neurologist at the Unit specialized in the care of the Dementias of the Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain;From 2006 to the present. I have participated as a subinvestigator in more than 10 Phase 2, 3 and 4 clinical trials I have participated in many research projects in the Dementia Unit in the following fields: genetics, genomics and clinics I add here some of my last publications: Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease. Alcolea D, Martínez-Lage P, Sánchez-Juan P, Olazarán J, Antúnez C, Izagirre A, Ecay-Torres M, Estanga A, Clerigué M, Guisasola MC, Sánchez Ruiz D, Marín Muñoz J, Calero M, Blesa R, Clarimón J, Carmona-Iragui M, Morenas-Rodríguez E, Rodríguez-Rodríguez E, Vázquez Higuera JL, Fortea J, Lleó A. Neurology. 2015 Aug 18;85(7):626-33. doi: 10.1212/WNL.0000000000001859. PMID: 26180139 Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer’s Disease. Moreno-Grau S, Barneda B, Carriba P, Marín J, Sotolongo-Grau O, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Espinosa A, Alegret M, Rodriguez O, Ortega G, Fernández MV, López-Arrieta J, Tárraga L, Boada M, Antúnez C, López J, Ruiz A, Comella JX. J Alzheimers Dis. 2015;45(2):621-9. PMID: 25613099 Genetic study of neurexin and neuroligin genes in Alzheimer's disease. Martinez-Mir A, González-Pérez A, Gayán J, Antúnez C, Marín J, Boada M, Lopez-Arrieta JM, Fernández E, Ramírez-Lorca R, Sáez ME, Ruiz A, Scholl FG, Real LM. J Alzheimers Dis. 2013;35(2):403-12. doi: 10.3233/JAD-122257. PMID: 23403532 Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease. Antúnez C, Boada M, López-Arrieta J, Moreno-Rey C, Hernández I, Marín J, Gayán J; Alzheimer's Disease Neuroimaging Initiative., González-Pérez A, Real LM, Alegret M, Tárraga L, Ramírez-Lorca R, Ruiz A. Alzheimers Dement. 2011 Jul;7(4):e124-9. doi: 10.1016/j.jalz.2011.05.2412. PMID: 21784344 The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Antúnez C, Boada M, González-Pérez A, Gayán J, Ramírez-Lorca R, Marín J, Hernández I, Moreno-Rey C, Morón FJ, López-Arrieta J, Mauleón A, Rosende-Roca M, Noguera-Perea F, Legaz-García A, Vivancos-Moreau L, Velasco J, Carrasco JM, Alegret M, Antequera-Torres M, Manzanares S, Romo A, Blanca I, Ruiz S, Espinosa A, Castaño S, García B, Martínez-Herrada B, Vinyes G, Lafuente A, Becker JT, Galán JJ, Serrano-Ríos M; Alzheimer's Disease Neuroimaging Initiative., Vázquez E, Tárraga L, Sáez ME, López OL, Real LM, Ruiz A. Genome Med. 2011 May 31;3(5):33. doi: 10.1186/gm249. PMID: 21627779 The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population. Ramírez-Lorca R, Boada M, Antúnez C, López-Arrieta J, Moreno-Rey C, Hernández I, Marín J, Gayán J, González-Pérez A, Alegret M, Tárraga L, Real LM, Ruiz A. J Alzheimers Dis. 2011;25(1):47-50. doi: 10.3233/JAD-2011-101983. PMID: 21383495 The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P. J Alzheimers Dis. 2010;22(1):247-55. doi: 10.3233/JAD-2010-100933. PMID: 20847397 Estrogen receptor alpha gene variants are associated with Alzheimer's disease. Boada M, Antunez C, López-Arrieta J, Caruz A, Moreno-Rey C, Ramírez-Lorca R, Morón FJ, Hernández I, Mauleón A, Rosende-Roca M, Martínez-Lage P, Marín J, Tárraga L, Alegret M, Pedrajas JR, Urda N, Royo JL, Saez ME, Gayán J, González-Pérez A, Real LM, Ruiz A, Galán JJ. Neurobiol Aging. 2012 Jan;33(1):198.e15-24. doi: 10.1016/j.neurobiolaging.2010.06.016. PMID: 20674091 CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model. Boada M, Antúnez C, López-Arrieta J, Galán JJ, Morón FJ, Hernández I, Marín J, Martínez-Lage P, Alegret M, Carrasco JM, Moreno C, Real LM, González-Pérez A, Tárraga L, Ruiz A. J Alzheimers Dis. 2010;20(1):247-51. doi: 10.3233/JAD-2010-1357. PMID: 20164592 GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population. Antúnez C, Boada M, López-Arrieta J, Ramirez-Lorca R, Hernández I, Marín J, Martínez-Lage P, González-Pérez A, Jorge Galan J, Gayán J, Real LM, Ruiz A. J Alzheimers Dis. 2009;18(4):751-4. doi: 10.3233/JAD-2009-1200. PMID: 19749441 Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease. Marín-Muñoz J, Noguera-Perea MF, Gómez-Tortosa E, López-Motos D, Antequera-Torres M, Martínez-Herrada B, Manzanares-Sánchez S, Vivancos-Moreau L, Legaz-García A, Rábano-Gutiérrez Del Arroyo A, Antúnez-Almagro C. J Alzheimers Dis. 2016 Apr 25;53(1):73-8. doi: 10.3233/JAD-160050. PMID: 27128372