Biography & Research:
My research agenda comprises two interconnected themes: (1) examining how alterations in brain and fluid biomarkers (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in probable Alzheimer’s disease, and (2) generating new knowledge concerning the modulation of the link between brain/fluid biomarker changes and cognitive decline by both modifiable (e.g., physical exercise, cognitively-stimulating activities) and non-modifiable (e.g., genetic vulnerability) factors. This work involves strong multidisciplinary teams, providing opportunities to demonstrate a consistent commitment to conducting high-quality, patient-oriented, aging research. The ultimate goal of my work is translational—the identification of people at greatest risk for Alzheimer’s disease and the development of therapeutic strategies for decreasing their risk.