Shireen Sindi, PhD

JAD profile

Associate Editor

Term Expiration: 

12/31/2024

Affiliation(s): 

Karolinska Institute

Areas of Interest: 

stress, sleep, lifestyle risk factors, prevention, clinical trials

Biography & Research: 

Shireen Sindi is Assistant Professor at Karolinska Institute, Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics. Her doctoral studies at McGill University (Canada) have focused on the associations between stress hormones, memory performance and hippocampal volume. Shireen is currently working within the Nordic Brain Network (PI: Professor Miia Kivipelto). The following summarises her current research activities in different projects related to preventive interventions for dementia and their implementation, as well as dementia risk factors such as psychological and physiological stress, sleep and associated biomarkers: PI and Scientific Coordinator: Multi-centre sleep study. The project combines four Nordic population-based studies (From Sweden and Finland) to assess the associations between sleep and dementia, cognition, MRI measures, biomarkers. Scientific and Research Coordinator: Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies (MIND-AD) (http://www.mind-ad.eu/). The goal is to identify effective prevention strategies for dementia based on experiences/data from 5 ongoing European dementia prevention trials. For the first time, a pilot trial will test a multimodal preventive intervention among patients with prodromal Alzheimer’s disease. Scientific and Research Coordinator: Multimodal strategies to promote a healthy brain in aging: Innovative evidence-based tools (MULTI-MODE). The goal is to develop and commercialise innovative evidence-based eHealth tools for dementia risk prediction and multidomain lifestyle intervention to prevent cognitive impairment/dementia. The products are designed for usage by citizens and health professionals. (http://ki.se/en/nvs/eit-health-project-aims-to-prevent-dementia-by-developing-new-innovations) Scientific and Research Coordinator: Cortisol and Stress in Alzheimer’s Disease (Co-STAR). Investigation of stress-related clinical and biomarker profiles and their association with cognition/dementia and neuroimaging correlates, in a population of memory clinic patients at the Karolinska University Hospital (Huddinge) Memory Clinic Conducting analyses & writing articles: The role of telomere length in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Conducting analyses & writing articles: The role of midlife work-related stress and dementia, cognition and MRI measures in the Cardiovascular Risk Factors, Aging and Incidence of Dementia study (CAIDE) She is also actively involved in supervision, teaching & several academic activities.