Biography & Research:
Our research interests are focused on brain development, especially neuronal migration, morphogenesis, synapse formation, glutamate receptors and synaptic plasticity. We aim to understand the cellular and molecular processes implicated in neurodegenerative diseases and developmental disorders including autism, Angelman syndrome, intellectual disability and Alzheimer’s disease. We use diverse techniques including biochemistry, immunofluorescent staining, live imaging, virus injection, in utero electroporation, electrophysiology and animal behavior tests. Specific research directions including AMPA receptor trafficking and ubiquitination-dependent degradation; homeostatic synaptic plasticity; neuron morphogenesis and synaptogenesis; as well as the cellular/molecular mechanisms underlying autism.