Biography & Research:
I am a genetic epidemiologist with over 20 years of experience in the study design and data analysis of genetic and behavioral factors of age-related complex diseases, particularly biomarkers and preclinical traits related to Alzheimer’s disease (AD). My research program uses statistical and bioinformatic approaches for cleaning, processing, and analyzing large-scale ‘omic data, including that from whole-genome array genotyping, whole-exome and -genome sequencing and metabolomic and lipidomic mass spectrometry. My program also utilizes analytic methods, including network analysis, Mendelian randomization, and mediation analysis, to integrate biomedical, genomic, and metabolomic data to understand, predict, prevent, and/or treat age-related health conditions, with a focus on Alzheimer’s disease.