Sakae Yumoto,

JAD profile

Affiliation(s): 

Yumoto Institute of Neurology

Areas of Interest: 

Alzheimer’s disease, oxidative stress, neurodegeneration, aluminum neurotoxicity, metals, Parkinson’s disease, electron microscopy, energy-dispersive spectroscopy, accelerator mass spectroscopy

Biography & Research: 

Sakae Yumoto, M.D., Ph.D. is studying the pathogenesis of Alzheimer’s disease (AD) at Yumoto Institute of Neurology in Shinjuku-ku, Tokyo, Japan. He graduated from the University of Tokyo Graduate School of Medicine. He worked as a teaching and research staff at the Tokyo University. After the retirement from the Tokyo University, he established Yumoto Institute of Neurology to continue his study. He demonstrated the incorporation of aluminum (Al-26) into the neuronal nuclei of rat brains through blood-brain barrier by accelerator mass spectrometry. He also demonstrated aluminum in the neuronal nuclei of the bran of patient with AD. Additionally, he showed the presence of aluminum in the senile plaques in the AD brain. Recently, he demonstrated colocalization of iron and aluminum in the neuronal nuclei of the brain of AD patients. He hypothesized that colocalization of iron and aluminum might cause severe oxidative damage to nuclear DNA (nDNA) through Fenton reaction, and the accumulation of nDNA damage in neurons might be considered to be a major factor in AD development.