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Leiden University; Leipzig University
Areas of Interest:
Alzheimers' disease; neurodegeneration; magnetic resonance imaging; NMR; metabolomics
Biography & Research:
In my group we are developing non-invasive magnetic resonance imaging (μMRI) methods to detect early, subtle changes in Alzheimer's disease brain for early diagnosis and providing accurate clinical evaluation of AD. We focus on visualizing amyloid plaque development in vivo in transgenic mouse models of AD at ultra-high magnetic fields (7T, 9.4T and 17.6T). In addition, cerebral amyloid angiopathy (CAA) related blood flow defects are being examined using magnetic resonance angiography. For understanding the mechanism of AD progression, we are getting direct access to the in vivo metabolic profile with very high selectivity and resolution using localized version of two dimensional magnetic resonance spectroscopy (L-COSY, J-PRESS), which we recently developed for accessing the chemistry of the live mouse brain. Within the network of collaboration between the Paul Flechsig Institute for brain research, the Institute for Medical Physics and Biophysics at Leipzig University and the University of Leiden (The Netherlands), we are particularly interested in: (1) dissecting the underlying mechanism for gender related differences in AD progression and (2) understanding the role of altered biological clock in Alzheimer's disease.