Biography & Research:
I am a National Institute on Aging Butler-Williams Scholar and my interests have centered on the impact of aging on the cardiovascular and nervous systems since the beginning of my career in the biomedical sciences. I believe that physiology/pathology research in the context of development and aging is the most effective approach for prevention and/or treatment of all major chronic diseases. The current goals of my laboratory directly center on investigation of endothelial function in pial arteries as well as throughout the brain microcirculation (e.g., arterioles) as an etiological source during cerebrovascular aging and the development of Alzheimer’s disease (AD). We suspect that AD begins as a cerebrovascular disease and that we can delay or prevent it altogether by optimizing cerebrovascular ion channel activity. With applying our fine control over cerebrovascular electrophysiology, we envision therapy for re-calibrating optimal cerebral perfusion as needed. Altogether, we believe that now pairing new found knowledge of vascular “signatures” with the developmental phases of AD may offer unprecedented opportunities to maintain a healthy mind throughout the entirety of a standard lifespan (~80 to 100 years).