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Erwin Roggen, PhD
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Affiliation(s):
ToxGenSolutions; 3Rs Managementa and Consulting; SenzaGen
Lab URL:
ORCID URL:
Areas of Interest:
novel approach methods (NAMs), neurodegeneration, cancer, immunosuppression, environmental and systemic risk factors
Biography & Research:
Dr. Erwin L Roggen holds a degree in Biochemistry from the University of Antwerp (1984). As postdoctoral fellow he acquired additional knowledge/expertise in protein chemistry, molecular biology, microbiology, immunology, and cell biology (1984-1996). As Science Manager at Novozymes (1996-2015), he coordinated the development and implementation of novel approach methods for early decision-making and risk assessment. In this function, he acquired experience in management of toxicological and pharmacological R&D projects. He coordinated the FP6 Project Sens-it-iv (2005-2011). He functioned as work package leader and board member of the FP6 Project carcinoGENOMICS (2006-2012) and the FP6 COST project impARAS (2014-2018).
He started 3Rs Management and Consulting ApS (2009), a non-profit initiative promoting implementation and application of promising mechanism-based novel approach methods by industry and regulatory authorities. In this function, he contributed to the AOPs for skin and respiratory sensitization and initiate an AOP for food sensitization. He is the co-founder of SenzaGen AB (2011), specialized in cell-based solutions to identify sensitizers, including proteins, based on key events of AOPs for skin and lung sensitization, and ToxGenSolutions BV (2015) providing industry with human relevant peripheral biomarker-based tools for preventive medicine covering key processes leading to neurodegeneration, immunosuppression and carcinogenesis that are affected by environmental and systemic risk factors. No animals are used. The current focus is the development of a peripheral biomarker profile for diagnosis of prodromal late-onset Alzheimer’s Disease based on key events of a proposed tau-driven AOP leading to memory loss.
He is or has been active in several national (e.g., Danish 3Rs Center, RE-PLACE Vlaanderen and Brussels Commission for Animal Experimentation), European (e.g., ECHA, ecopa, EPAA, ESAC, IVTIP) and global (e.g., WHO, OECD) organizations. He has been involved in the discussions leading to the AOP for skin sensitization and is still part of the group developing an AOP for lung sensitization.